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FLASH GENE
Symbol RAB10 contributors: mct - updated : 04-12-2018
HGNC name RAB10, member RAS oncogene family
HGNC id 9759
Location 2p23.3      Physical location : 26.256.728 - 26.360.322
Synonym name
  • ras-related GTP-binding protein RAB10
  • GTP-binding protein RAB10
  • DNA
    TYPE functioning gene
    STRUCTURE 104.53 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 3785 22.5 200 - - 9918381
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticthymus   highly
    Cardiovascularheart   lowly
    Digestivemouth   highly
    Endocrinepancreas   highly
    Nervousbrain   highly
    Reproductivemale systemprostate  highly
    Respiratoryrespiratory tracttrachea  highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Urinaryepithelial cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated LipoP , Other
    HOMOLOGY
    interspecies ortholog to murine Rab10
    homolog to Drosophila rab10
    homolog to C.elegans 4R79.2 and T23H2.5
    homolog to yeast Sec4p protein
    Homologene
    FAMILY
  • small GTPase superfamily
  • RAS family
  • CATEGORY protooncogene , transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic,vesicle
    intracellular,cytoplasm,cytoskeleton,microtubule
    text
  • associates with primary cilia in renal epithelia
  • RAB10 localizes to the ER and to dynamic ER-associated structures that track along microtubules and mark the position of new ER tubule growth
  • RAB10 colocalized with HAS3 in intracellular vesicular structures and was co-immunoprecipitated with HAS3 from isolated endosomal vesicles
  • subcellular localizations include the endoplasmic reticulum (ER), Golgi/TGN, the endosomes/phagosomes and the primary cilia (pMID: 29377137)
  • basic FUNCTION
  • involved in vesicular trafficking and neurotransmitter release
  • having functions in trafficking from the Golgi at early stages of epithelial polarization, is involved in biosynthetic transport to the basolateral membrane and may co-operate with RAB8
  • implicated in insulin-stimulated SLC2A4 translocation
  • small GTPase which is essential for optimal macrophage activation following lipopolysaccharide stimulation
  • its expression provides a mechanism to refine TLR4 signaling by regulating the trafficking rate of TLR4 onto the plasma membrane
  • RAB10 and EHBP1 function together in many cell types, suggesting that there are differences in the level of redundancy among Rab family members in polarized versus nonpolarized cells
  • RAB10 is likely involved in insulin-stimulated translocation of SLC2A4 storage vesicle (GSV) to the Plasma membrane, with RAB14 involved in insulin-stimulated translocation of SLC2A4-containing endosome
  • is an ER-specific Rab GTPase that regulates ER structure and dynamics
  • MIA3 and RAB10 are planar polarized at the basal epithelial surface
  • novel function for RAB10 in reducing cell surface HAS3, suppressing hyaluronan (HA) synthesis, and facilitating cell adhesion to type I collagen
  • RAB10 promotes likely the ability of endosome-bound EHBP1 to also bind to the actin cytoskeleton, thereby promoting endosomal tubulation
  • is a regulator of insulin-stimulated translocation of the SLC2A4 glucose transporter to the plasma membrane (PM) of adipocytes, which is essential for whole-body glucose homeostasis
  • SEC16A and RAB10 promote insulin-stimulated mobilization of SLC2A4 from a perinuclear recycling endosome/TGN compartment
  • regulates cell survival and proliferation through multiple oncogenic, cell stress and apoptosis pathways
  • RAB10 has been implicated in a myriad of activities ranging from polarized exocytosis and endosomal sorting in polarized cells, insulin-dependent SLC2A4 transport in adipocytes, axonal growth in neurons, and endo-phagocytic processes in macrophages
  • small Rab GTPase involved in vesicular trafficking
  • stress-responsive machinery composed of RAB29, LRRK2, phosphorylated RAB8/RAB10, and their downstream effectors implicated in the maintenance of lysosomal homeostasis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS exocytosis transport
    text protein transport
    PATHWAY
    metabolism
    signaling neurotransmission
    a component
  • RAB3IP, RAB10, and the microtubule minus-end-directed kinesin KIFC3 form a peroxisome-associated complex to control the movement of peroxisomes along microtubules, enabling communication between peroxisomes and ciliary pocket membranes
  • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    GTP
    protein
  • EVI5L interacting with RAB10
  • target of TBC1D4 (functions as a downstream target of TBC1D4 in the insulin-signaling pathway that regulates SLC2A4 translocation in adipocytes)
  • interacting with GDI1 in insulin-stimulated SLC2A4 translocation
  • CRISPLD2 interacted with and activated RAB10, a small GTPase that mediates membrane protein trafficking, by releasing GDP dissociation inhibitor (GDI) from RAB10
  • RAB10 and RAB14 mediate insulin-stimulated SLC2A4 translocation, respectively, of SLC2A4 storage vesicle (GSV) and endosomal compartments
  • RAB10 interacts with the actin motor protein MYO5A, and this facilitates the translocation of GSVs to sites at the PM where they can fuse
  • AGAP3 targets RAB10 to structures in the basal cytoplasm, where it restricts protein delivery to the basal surface
  • RAB10 interaction with myosin Vb (MYO5B) determines the formation of RAB10 carriers and is important for axon development
  • MARCKS mediates membrane targeting of RAB10-positive plasmalemmal precursor vesicles (PPVs), and this regulation is critical for axon development
  • RAB10 recruits RGL2 to membrane compartments for RALA activation and RALA is downstream of RAB10
  • association of RAB10-GTP with EXOC6/6B is a molecular link between insulin signaling and the exocytic machinery in SLC2A4 translocation
  • SLC2A4 traffics predominantly through the specialized RAB10-dependent pathway both before and after insulin stimulation
  • EHBP1 is a conserved regulator of endocytic recycling, acting as an effector of small GTPases including RAB10
  • TBC1D21 is involved in mammalian spermiogenesis by modulating RAB10
  • RAB10 is a key substrate of LRRK2, a serine/threonine protein kinase genetically associated with the second most common neurodegenerative disease Parkinson disease
  • cell & other
  • interactions between RAB10 and an exocyst complex (membrane transport to the primary cilum may be mediated by this interactions located at the cilium base)
  • REGULATION
    Phosphorylated by LRRK2 (LRRK2 phosphorylates members of the Rab GTPase family, including RAB10, under physiological conditions)
    Other RAB10 phosphorylation could be responsible for aberrations in the vesicle trafficking observed in Alzheimer disease leading to neurodegeneration
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional        
    blocked the retrograde traffic of HAS3 from the plasma membrane to early endosomes
    tumoral     --over  
    in hepatocellular carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • is a potential biomarker for hepatocellular carcinoma
  • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestiveliver
    is a potential molecular target or a biomarker for hepatocellular carcinoma (PMID: 28460436)
    respiratorylung 
    possible therapeutic target for human acute respiratory distress syndrome (ARDS)
    ANIMAL & CELL MODELS