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FLASH GENE
Symbol QSOX1 contributors: mct - updated : 30-04-2010
HGNC name quiescin Q6 sulfhydryl oxidase 1
HGNC id 9756
Location 1q25.2      Physical location : 180.123.967 - 180.167.167
Synonym name
  • quiescin Q6
  • sulfhydryl oxidase 1
  • Synonym symbol(s) Q6, QSCN6, FLJ34858
    EC.number 1.8.3.2
    DNA
    TYPE functioning gene
    STRUCTURE 43.20 kb     13 Exon(s)
    MAPPING cloned Y linked N status provisional
    regionally located located near HPC1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 2583 - 604 . secreted Coppock (1998)
  • isoform b
  • 12 - 3316 82 747 . Golgi Coppock (1998)
  • isoform a
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveliver    
    Endocrinepancreas    
    Nervousbrain   lowly
    Reproductivefemale systemplacenta   
    Respiratorylung    
    Urinarykidney   lowly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text lung fibroblasts
    life cycle quiescence
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one ERV/ALR sulfhydryl oxidase domain
  • one thioredoxin domain (direct interaction between the reduced thioredoxin domain and ERV/ALR sulfhydryl oxidase domain)
  • conjugated FlavoP , GlycoP
    mono polymer monomer
    HOMOLOGY
    interspecies homolog to rattus Qsox1 (77.6pc)
    Homologene
    FAMILY
  • quiescin-sulfhydryl oxidase (QSOX) family
  • Erv family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • putatively involved in cell adhesion
  • regulating entrance into quiescence
  • may contribute to disulfide bond formation in a variety of secreted proteins
  • in fibroblasts, may have tumor-suppressing capabilities being involved in growth regulation
  • rapidly inserts disulfide bonds into unfolded, reduced proteins with the concomitant reduction of oxygen to hydrogen peroxide
  • CELLULAR PROCESS cell cycle, progression
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
  • one FAD per subunit
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS