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Symbol PYY contributors: mct - updated : 11-09-2015
HGNC name peptide YY
HGNC id 9748
Location 17q21.31      Physical location : 42.030.108 - 42.081.837
Synonym symbol(s) NPYY, PYY1
TYPE functioning gene
STRUCTURE 71.53 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
Physical map
ARHN 17q21 ras homolog gene family, member N BRCA1 17q21 breast cancer 1, early onset RPL21P4 17q21 ribosomal protein L21 pseudogene 4 NBR2 17q21 neighbor of BRCA1 gene 2 LOC387620 17 membrane component, chromosome 17, surface marker 2 MGC20235 17q21.31 hypothetical protein MGC20235 LOC388388 17 LOC388388 RNU2P2 17q21.31 RNA, U2 small nuclear pseudogene 2 ARF4L 17q12-q21 ADP-ribosylation factor 4-like LOC284064 17q21.31 similar to 60S ribosomal protein L29 (Cell surface heparin binding protein HIP) DHX8 17q21.31 DEAH (Asp-Glu-Ala-His) box polypeptide 8 ETV4 17q21 ets variant gene 4 (E1A enhancer binding protein, E1AF) MEOX1 17q21 mesenchyme homeo box 1 LOC390797 17 similar to WHSC1L1 protein isoform long; Wolf-Hirschhorn syndrome candidate 1-like 1 protein SOST 17q12-q21 sclerosteosis DUSP3 17q21 dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related) LOC284067 17q21.31 hypothetical LOC284067 MPP3 17q12-q21 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3) TREM4 17q21.31 triggering receptor expressed on myeloid cells 4 MPP2 17q12-q21 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) APR-2 17q21.31 apoptosis related protein LOC390798 17 similar to wingless-type MMTV integration site family, member 9B precursor; wingless-type MMTV integration site family, member 15 PPY 17q21.2 pancreatic polypeptide PYY 17q21.1 peptide YY NAGS 17q21.31 peptide YY MGC4251 17q21.31 hypothetical protein MGC4251 FLJ30656 17q21.31 hypothetical protein FLJ30656 G6PC3 17q21.31 glucose-6-phosphatase catalytic subunit 3 HDAC5 17q21 histone deacetylase 5 MGC3130 17q21.31 hypothetical protein MGC3130 ASB16 17q21.31 ankyrin repeat and SOCS box-containing 16 DKFZp762C2414 17q21.31 hypothetical protein DKFZp762C2414 MGC3123 17q21.31 hypothetical protein MGC3123 UBTF 17q21.3 upstream binding transcription factor, RNA polymerase I LOC390799 17 similar to SHC (Src homology 2 domain containing) transforming protein 1; SHC (Src homology 2 domain-containing) transforming protein 1 SLC4A1 17q21-q22 solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group) RPIP8 17p13.2 solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group) CGI-69 17q12 CGI-69 protein GRN 17q21.3 granulin MGC34829 17q21.31 Similar to hypothetical gene supported by AL050367; AK022946 LOC390800 17 similar to ribosomal protein L7-like 1 ITGA2B 17q21.32 integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B) KIAA0553 17q21.31 KIAA0553 protein FZD2 17q21.1 frizzled homolog 2 (Drosophila) FLJ35848 17q21.31 hypothetical protein FLJ35848 FLJ31795 17q21.31 hypothetical protein FLJ31795 DRF1 17q21.31 Dbf4-related factor 1 ADAM11 17q21.3 a disintegrin and metalloproteinase domain 11 GJA7 17q21.31 gap junction protein, alpha 7, 45kDa (connexin 45) CLST11240 17q21.31 CLST 11240 protein U5-116KD 17q21.31 U5 snRNP-specific protein, 116 kD
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 1069 - 97 - 2009 19651163
  • PYY1-36
  • - - - - - - 2009 19651163
  • truncated isoform
  • reducing effect upon food intake might be mediated by a decreased gastric emptying rate
  • is a satiation hormone released postprandially into the bloodstream from L-endocrine cells in the gut epithelia
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon   Homo sapiens
     intestinesmall intestineileum   Homo sapiens
    Reproductivemale systemtestis   
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialabsorptive excretorydigestive epithelium (mucosa)   Homo sapiens
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmonocyte Homo sapiens
    cell lineage
    cell lines
    at STAGE
  • a N terminal tyrosine
  • a C terminal tyrosinamide, with a C-terminal helix crucial for the structural integrity of PYY
    FAMILY NPY family
    CATEGORY signaling
    basic FUNCTION
  • gut hormone, inhibiting exocrine pancreatic secretion, having a vasoconstrictory action and inhibiting jejunal and colonic mobility
  • implicated in the control of food intake
  • prandially controlled hormone in endocrine ileal and colonic mucosa cells
  • glucose-stimulated secretion of GCG and PYY is reduced by a sweet taste antagonist, suggesting the functional involvement of gut-expressed sweet taste receptors in glucose-stimulated secretion of both peptides in humans
  • in the digestive tract, NPY and PYY inhibit gastrointestinal motility and electrolyte secretion and in this way modify the input to the brain
  • similar to other neuroendocrine peptides/amines of the gut, PYY has broad physiological/pharmacological effects: it can bind to and activate several receptors with independent actions
    text pancreas
    signaling hormonal
    a component
    small molecule
  • apical PYY was able to decrease cholesterol uptake via NPC1L1 downregulation
  • Gln stimulates the co-release of endogenous GCG and PYY from mucosal L-cells resulting in paracrine GCG and Y1 receptor-mediated electrogenic epithelial responses
  • cell & other
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       gain of function
    in obesity
    Susceptibility to obesity
    Variant & Polymorphism other Q62P variant linked to obesity
    Candidate gene
    Therapy target