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FLASH GENE
Symbol PYGO1 contributors: - updated : 05-07-2005
HGNC name pygopus homolog 1 (Drosophila)
HGNC id 30256
Location 15q21.1      Physical location : 55.838.220 - 55.881.050
DNA
TYPE functioning gene
STRUCTURE 42.00 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon  
Reproductivefemale systemuteruscervix  
Visualeye    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a PHD-type zinc finger
    • mono polymer complex
    HOMOLOGY
    interspecies ortholog to murine Pygo1
    Homologene
    FAMILY
    CATEGORY regulatory , transcription factor , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved in signal transduction through the Wnt pathway
  • playing a role in the regulation of transcription, DNA-dependent
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    Wnt pathway
    a component
  • part of the nuclear beta-catenin/TCF complex
    • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
    • protein
  • BCL9 via The PHD-type zinc finger motif
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS