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FLASH GENE
Symbol PYGB contributors: - updated : 27-01-2007
HGNC name phosphorylase, glycogen; brain
HGNC id 9723
Location 20p11.2      Physical location : 25.228.705 - 25.278.647
Synonym name
  • brain glycogen phosphorylase
  • Synonym symbol(s) MGC9213
    EC.number 2.4.1.1
    DNA
    TYPE functioning gene
    STRUCTURE 49.00 kb     20 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    CST4 20p11.2 cystatin S CST1 20p11.2 cystatin SN CSTP2 20p11.2 cystatin pseudogene 2 CST2 20p11.2 cystatin SA CST5 20p11.21 cystatin D CSTP1 20p11.2 cystatin pseudogene 1 GGTLA4 20p11.1 gamma-glutamyltransferase-like activity 4 LOC284796 20p11.21 similar to hypothetical protein DKFZp434P211.1 - human (fragments) C20orf39 20p11.21 chromosome 20 open reading frame 39 LOC391238 20 LOC391238 CST7 20p11.22-p11.21 cystatin F (leukocystatin) C20orf3 20p11.22-p11.21 chromosome 20 open reading frame 3 ACAS2L 20p11.23-p11.21 acetyl-Coenzyme A synthetase 2 (AMP forming)-like VSX1 20p11.23-p11.22 visual system homeobox 1 homolog, CHX10-like (zebrafish) LOC391239 20 similar to immune costimulatory protein B7-H4 LOC391240 20 similar to nodulin ENTPD6 20q11.2 ectonucleoside triphosphate diphosphohydrolase 6 (putative function) PYGB 20p11.2 phosphorylase, glycogen; brain C20orf22 20 chromosome 20 open reading frame 22 PPIAP2 20 peptidylprolyl isomerase A (cyclophilin A) pseudogene 2 KIAA0186 20pter-cen peptidylprolyl isomerase A (cyclophilin A) pseudogene 2 KIAA0980 20p11.2-p11.1 peptidylprolyl isomerase A (cyclophilin A) pseudogene 2 C20orf147 20p11.1 chromosome 20 open reading frame 147 ZNF337 20p11.1 zinc finger protein 337 C20orf189 20 chromosome 20 open reading frame 189 FLJ38374 20p11.21 hypothetical protein FLJ38374 LOC149934 20p11.21 similar to bB329D4.2.1 (novel protein similar to a truncated nuclear receptor co-repressor 1 (NCOR1) (retinoid X receptor interacting protein 13), isoform 1)
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly
    Nervousbrain    
     nerve   highly
    Skin/Tegumentskin   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY glycogen phosphorylase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION catalyzes the rate-determining step in glycogen degradation
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component forms homodimers which can associate into homotetramers, the enzymatically active form of glycogen phosphorylase
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
    pyridoxal phosphate
    protein
    cell & other
    REGULATION
    activated by by AMP
    inhibited by ATP, ADP, and glucose-6-phosphate
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS