Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PYDC1 contributors: mct/npt - updated : 04-07-2008
HGNC name pyrin domain containing 1
HGNC id 30261
Location 16p11.2      Physical location : 31.227.283 - 31.228.395
Synonym name
  • pyrin-only protein 1
  • PAAD [pyrin, AIM (absent-in-melanoma)
  • ASC [apoptosis-associated speck-like protein containing a CARD (caspase-recruitment domain and DD (death domain)-like]-only protein-1
  • PYD only protein 1
  • Synonym symbol(s) POP1, PYC1, ASC2, ASCI
    DNA
    TYPE functioning gene
    STRUCTURE 1.00 kb     2 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 582 10.1 89 - Natarajan (2006)
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveintestinesmall intestine   
    Lymphoid/Immunespleen    
    Respiratorylung    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one CARD domain
  • one DAPIN domain
  • secondary structure six-helix bundle structure with a prominent loop, comprising 13 amino acid residues, between helices two and three
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • promoting caspase-mediated apoptosis predominantly through the activation of caspase 9
  • functions as a modulator of multidomain PYD-containing proteins involved in NF-kappaB and caspase-1 activation
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with PYCARD
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS