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FLASH GENE
Symbol PXK contributors: mct/npt - updated : 12-07-2010
HGNC name PX domain containing serine/threonine kinase
HGNC id 23326
Location 3p14.3      Physical location : 58.318.616 - 58.410.878
Synonym name
  • PX serine/threonine kinase
  • modulator of Na,K-ATPase long form
  • PX ser/thr kinase v2
  • Synonym symbol(s) FLJ20335, MONaKA
    DNA
    TYPE functioning gene
    STRUCTURE 92.26 kb     18 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    RAP140 3p21.31 retinoblastoma-associated protein 140 ARHGEF3 3p21-p13 Rho guanine nucleotide exchange factor (GEF) 3 SPATA12 3p21.2 spermatogenesis associated 12 IL17RD 3p21.1 interleukin 17 receptor D HESX1 3p21.2-p21.1 homeo box (expressed in ES cells) 1 APPL 3p21.1-p14.3 homeo box (expressed in ES cells) 1 ASB14 3p21.1 ankyrin repeat and SOCS box-containing 14 FLJ40427 3p21.2 hypothetical protein FLJ40427 FLJ44290 3p21.2 FLJ44290 protein DKFZp667B1218 3p21.2 hypothetical protein DKFZp667B1218 ARF4 3p21.2-p21.1 ADP-ribosylation factor 4 FLJ34969 3p21.2 hypothetical protein FLJ34969 SLMAP 3p21.2-p14.3 sarcolemma associated protein LOC344797 3p21.2 similar to peptidylprolyl isomerase A FLNB 3p14.3 filamin B, beta (actin binding protein 278) DNASE1L3 3p21.1-p14.3 deoxyribonuclease I-like 3 ABHD6 3p21.2 abhydrolase domain containing 6 RPP14 3p21.2 ribonuclease P (14kD) PXK 3p21.2 PX domain containing serine/threonine kinase PDHB 3p21.1-p14.3 pyruvate dehydrogenase (lipoamide) beta KCTD6 3p21.2 potassium channel tetramerisation domain containing 6 ACOX2 3p14.3 acyl-Coenzyme A oxidase 2, branched chain TU3A 3p21.1 Homo sapiens TU3A protein (TU3A), mRNA. LOC389126 3 LOC389126 FAM3D 3p21.1 family with sequence similarity 3, member D FLJ42117 3p21.2 FLJ42117 protein LOC339902 3p21.2 hypothetical LOC339902
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    18 - 2048 65 578 - Zou (2005)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node   highly
    Nervousbrain   highly
     nerve   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a PX domain, which localizes this protein to the endosomal membrane via binding to phosphatidylinositol 3-phosphate (Takeuchi 2010)
  • a protein kinase-like domain
  • a proline-rich region
  • a WASP homology 2 domain,that is a functional actin-binding domain (Takeuchi 2010)
  • HOMOLOGY
    interspecies homolog to murine D14Ertd813e
    homolog to rattus Pxk
    Homologene
    FAMILY
  • protein kinase superfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    text localized to the endosomal membrane via binding to phosphatidylinositol 3-phosphate (Takeuchi 2010)
    basic FUNCTION
  • modulates brain Na, K-ATPase and may thereby participate in the regulation of electrical excitability and synaptic transmission
  • plays a critical role in epidermal growth factor receptor trafficking through modulating ligand-induced ubiquitination of the receptor (Takeuchi 2010)
  • promotes the ubiquitination of EGFR and thus the following endolysosomal trafficking for degradation (Takeuchi 2010)
  • may be playing an an important role in the immune system (Takeuchi 2010)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
  • protein
  • interacts with and modulates the plasma membrane Na,K-ATPase
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to systemic lupus erythematosus
    Variant & Polymorphism other increasing the risk of systemic lupus erythematosus
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS