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FLASH GENE
Symbol PWWP2A contributors: mct - updated : 04-06-2019
HGNC name PWWP domain containing 2A
HGNC id 29406
Location 5q33.3      Physical location : 159.502.893 - 159.546.452
Synonym symbol(s) MST101
DNA
TYPE functioning gene
STRUCTURE 77.16 kb     4 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 3898 - 520 - 2018 30327463
4 - 4018 - 560 - 2018 30327463
4 - 3968 - 303 - 2018 30327463
4 - 4088 - 343 - 2018 30327463
5 - 4016 - 303 - 2018 30327463
2 - 3373 - 755 - 2018 30327463
4 - 4680 - 538 - 2018 30327463
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • PWWP domain exhibiting direct DNA binding
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • vertebrate-specific protein that binds very tightly to chromatin through a concerted multivalent binding mode (pMID: 28645917)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PWWP2A is a novel H2AFZ-nucleosome binder
  • PWWP2A is a novel H2AFZ-specific multivalent chromatin binder providing a surprising link between H2AFZ, chromosome segregation, and organ development
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS