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FLASH GENE
Symbol PVRL3 contributors: mct/shn/pgu - updated : 01-06-2010
HGNC name poliovirus receptor-related 3
HGNC id 17664
Location 3q13.13      Physical location : 110.790.864 - 110.853.062
Synonym name
  • afadin-associated molecule
  • nectin 3
  • poliovirus receptor-related 3
  • Synonym symbol(s) PPR3, PRL3, NECT3, PRR3, CD113, PVRR3, CDw113, FLJ90624, nectin-3, DKFZp566B0846
    DNA
    TYPE functioning gene
    STRUCTURE 62.20 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map cen - D3S3695 - D3S4017 - PVRL3 - D3S4551 - D3S2496 - qter
    Physical map
    RETNLB 3q13.1 resistin like beta TRIM 3q13 resistin like beta GUCA1C 3q13.1 guanylate cyclase activator 1C MORC 3q13 microrchidia homolog (mouse) LOC151871 3q13.13 hypothetical protein BC018070 DPPA4 3q13.13 developmental pluripotency associated 4 LOC391564 3 similar to H3 histone, family 3B LOC391565 3 similar to peptidyl-Pro cis trans isomerase LOC389140 3 similar to Nuclear transcription factor Y subunit beta (NF-Y protein chain B) (NF-YB) (CCAAT-binding transcription factor subunit A) (CBF-A) (CAAT-box DNA binding protein subunit B) LOC389141 3 similar to laminin receptor 1 (ribosomal protein SA); P40-3, functional; P40-8, functional; laminin receptor 1 (67kD, ribosomal protein SA) LOC151760 3q13.13 hypothetical LOC151760 PVRL3 3q13 hypothetical LOC151760 CD96 3q13.13 CD96 antigen ZBED2 3p13-q13.2 zinc finger, BED domain containing 2 FLJ31579 3q13.13 hypothetical protein FLJ31579 LL5beta 3q13.13 LL5 beta FLJ11342 3q13.13 hypothetical protein FLJ11342 NP25 3q13.13-q13.2 neuronal protein TMPRSS7 3q13.2 type II transmembrane serine protease 7 FLJ23186 3q13.2 hypothetical protein FLJ23186 GCET2 3q13.2 germinal center expressed transcript 2 LOC285335 3q13.2 hypothetical protein LOC285335 MOX2 3q12-q13 antigen identified by monoclonal antibody MRC OX-2 BTLA 3q13.2 B and T lymphocyte associated APG3 3q13.2 B and T lymphocyte associated SLC35A5 3q13.2 solute carrier family 35, member A5 URB 3q13.2 steroid sensitive gene 1 LOC344807 3q13.2 similar to Cell surface glycoprotein OX2 receptor precursor (CD200 cell surface glycoprotein receptor) CD200R 3q13.2 cell surface glycoprotein receptor CD200 HSPC135 3q13.2 HSPC135 protein DKFZP434F2021 3q13.2 DKFZP434F2021 protein BOC 3q13.2 brother of CDO FLJ11142 3q13.2 hypothetical protein FLJ11142 LOC152185 3q13.2-q13.31 hypothetical protein AY099107
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1650 - 549 - 2000 11024295
    EXPRESSION
    Rna function mRNA is localized along the heterotypic junctions between hair cells and supporting cells
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Hearing/Equilibriumearinnercochlea   Homo sapiens
    Nervousbrainlimbic systemhippocampus   Homo sapiens
    Reproductivefemale systemplacenta  predominantly
     male systemtestis  predominantly
    Visualeyelens    Mus musculus
     eyeanterior segment    Mus musculus
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Hearing / Equilibriumhair cell receptor Homo sapiens
    cell lineage highly expressed in rabbit limbal epithelial side population (rLE-SP) cells
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text placenta ,eye
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three extracellular Ig-like domains (V,C and C)
  • a consensus sequence A/EXYY for binding the PDZ domain
  • HOMOLOGY
    interspecies ortholog to Pvrl3, Mus musculus
    ortholog to pvrl3l, Danio rerio
    Homologene
    FAMILY nectin family
    CATEGORY adhesion
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
    text localized in epithelial cell-cell junctions in renal proximal tubules and in the amniotic membrane)
    basic FUNCTION
  • homophilic and heterophilic cell-cell adhesion activities
  • organizing adherens junctions cooperatively with the cadherin-catenin system in epithelial cells
  • expressed on normal cells of an epithelial origin, such as endothelial cells
  • critical gene involved in a Nectin-mediated cell-cell adhesion mechanism in human ocular development
  • promote the formation of the checkerboard-like pattern of the auditory epithelia
  • involved in formation of the mechanical adhesive puncta adherentia junctions of synapses
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) translocated to 4, MLLT4
  • par-3 partitioning defective 3 homolog (C. elegans), PARD3
  • PVR
  • molecular interaction between PVRL1 and PVRL33 is the strongest of all possible combinations of the three nectins, which is likely to be responsible for the checkerboard-like assembly of these cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Nectin-3(-/-) mice had defects in the later steps of sperm morphogenesis including distorted nuclei, abnormal distribution of mitochondria and in localization of nectin-2 at the Sertoli-spermatid junctions
  • Pvrl3 knockout mice as well as a spontaneous mouse mutant ari (anterior retinal inversion), that maps to the Pvrl3 locus, exhibit lens and other ocular defects involving the ciliary body