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FLASH GENE
Symbol PVRL2 contributors: mct - updated : 10-02-2010
HGNC name poliovirus receptor-related 2 (herpesvirus entry mediator B)
HGNC id 9707
Location 19q13.32      Physical location : 45.349.392 - 45.392.485
Synonym name
  • poliovirus receptor-related 2
  • nectin-2
  • Synonym symbol(s) PRR2, HVEB, PVRR2, CD112
    DNA
    TYPE functioning gene
    STRUCTURE 43.09 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Physical map
    LOC388549 19 LOC388549 ZNF285  zinc finger protein 285 ZNF229 19q13.2 zinc finger protein 229 LOC147711 19q13.32 similar to zinc finger protein 285 ZNF180 19q13.1-q13.3 zinc finger protein 180 (HHZ168) UNQ9366 19q13.32 GPAD9366 LOC388550 19 similar to CEACAM5 protein LOC390941 19 LOC390941 LOC147710 19q13.32 hypothetical LOC147710 PVR 19q13.2 poliovirus receptor CEAL1 19q13.32 carcinoembryonic antigen-like 1 LOC388551 19 similar to carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) BCL3 19q13.2 B-cell CLL/lymphoma 3 CBLC 19q13.2-q13.3 Cas-Br-M (murine) ecotropic retroviral transforming sequence c LU 19q12-q13 Lutheran blood group (Auberger b antigen included) PVRL2 19q13.2-q13.4 poliovirus receptor-related 2 (herpesvirus entry mediator B) TOMM40 19q13 translocase of outer mitochondrial membrane 40 homolog (yeast) APOE 19q13.2 apolipoprotein E APOC1 19q13.2 apolipoprotein C-I APOC4 19q13.2 apolipoprotein C-IV APOC2 19q13.2 apolipoprotein C-II CLPTM1 19q13.2 cleft lip and palate associated transmembrane protein 1 RELB 19q13.32 v-rel reticuloendotheliosis viral oncogene homolog B, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 (avian) SFRS16 19q13.3 splicing factor, arginine/serine-rich 16 (suppressor-of-white-apricot homolog, Drosophila) ZNF342 19q13.32 zinc finger protein 342 GEMIN7 19q13.32 gem (nuclear organelle) associated protein 7 EIF5AP3 19q13.2 eukaryotic translation initiation factor 5A pseudogene 3 LOC284352 19q13.32 hypothetical protein LOC284352 FLJ33600 19q13.32 FLJ33600 protein MGC2650 19q13.32 hypothetical protein MGC2650 LOC388552 19 similar to BC043666 protein XTP7 19q13.32 protein 7 transactivated by hepatitis B virus X antigen (HBxAg) MARK4 19q13.2 MAP/microtubule affinity-regulating kinase 4
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 splicing 1370 - 449 ubiquitous Yoshiura, Lopez (1998)
    9 splicing 2869 - 539 ubiquitous Warner, Lopez (1998)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly
     intestinesmall intestine  highly
    Reproductivefemale systemovary  highly
     male systemprostate  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • 2 Ig-like C2-type (immunoglobulin-like) domains
  • a Ig-like V-type (immunoglobulin-like) domain
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Mph gene
    Homologene
    FAMILY
    CATEGORY receptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • Herpes virus entry mediator B
  • Receptor for alphaherpesvirus (HSV-1, HSV-2 and pseudorabies virus) entry into cells
  • expressed on normal cells of an epithelial origin, such as endothelial cells (Stanietsky 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity (Pubmed 19815499)
  • ZYXPVRL2 interaction plays a critical role in zyxin targeting to these sites
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility putative susceptibility factor for Alzheimer's disease
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS