Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PURB contributors: mct - updated : 06-04-2012
HGNC name purine-rich element binding protein B
HGNC id 9702
Location 7p13      Physical location : 44.915.893 - 44.924.960
Synonym symbol(s) PURBETA, MGC126784, MGC126786
DNA
TYPE functioning gene
STRUCTURE 9.07 kb     1 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned   linked   status
RNA
TRANSCRIPTS type
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
1 - 9074 - 312 - 2003 12933792
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a core domain that is stably folded in the absence of glycine-rich N- and C-terminal sequences, interacting with purine-rich cis-elements from the smooth muscle alpha-actin gene
    • HOMOLOGY
    interspecies
    intraspecies homolog to PURA
    Homologene
    FAMILY small but highly conserved family of nucleic acid-binding proteins
    CATEGORY
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • PURalpha and PURbeta repressed alpha-myosin heavy chain (alpha-MHC) gene expression in the presence of upstream regulatory sequences of the gene
  • participate in transcriptional as well as translational regulation of alpha-MHC expression in cardiac myocytes
  • Pur alpha and Pur beta repress smooth muscle alpha-actin gene transcription by means of DNA strand-selective cis-element binding and cell type-dependent protein-protein interactions
  • structurally related single-stranded DNA/RNA-binding proteins implicated in the control of cell growth and differentiation
  • PURA, and PURB, collaborate with Sp3 to regulate a transcriptional program that enables muscle cells to remodel their phenotype
  • acting as a repressor of GNRH1 gene transcription
  • single-stranded nucleic acid-binding protein implicated in the injury-induced repression of genes encoding certain muscle-restricted isoforms of actin and myosin expressed in the heart, skeletal muscle, and vasculature
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • cooperative assembly of the dimeric PURB repressor on the sense strand of the ACTA2 enhancer is dictated by the association of each subdomain with distinct purine-rich binding sites within the enhancer
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS