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FLASH GENE

Symbol

PTX4

contributors: SGE/npt - updated : 13-07-2010

HGNC name	pentraxin 4, long
HGNC id	14171

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	16p13.3      Physical location : 1.535.940 - 1.538.468
Synonym name	chromosome 16 open reading frame 38
	neuronal pentraxin II-like
	neuronal pentraxin-like protein C16orf38
Synonym symbol(s)	C16orf38

DNA

TYPE	functioning gene
STRUCTURE	2.53 kb     3 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001013658 3 - 1422 NP_001013680 - 473 - Martinez de la Torre (2010)

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine     highly Lymphoid/Immune spleen           thymus         Nervous brain       lowly Reproductive male system testis     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow     highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

one pentaxin domain

conjugated

GlycoP

HOMOLOGY

Homologene

FAMILY

pentraxin (PTX) superfamily

CATEGORY

unknown/unspecified

SUBCELLULAR LOCALIZATION	extracellular
text	secreted

basic FUNCTION

may be part of the humoral arm of innate immunity and behave as functional ancestor of antibodies by mediating agglutination, complement activation and opsonization (Martinez de la Torre 2010)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	binding two Ca2+ ions per subunit

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS