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FLASH GENE
Symbol PTPRU contributors: - updated : 27-09-2004
HGNC name protein tyrosine phosphatase, receptor type, U
HGNC id 9683
Location 1pter-p35      Physical location : 29.563.027 - 29.653.325
Synonym name
  • protein tyrosine phosphatase,162kDa,receptor type
  • protein tyrosine phosphatase J
  • pancreatic carcinoma phosphatase 2
  • protein tyrosine phosphatase receptor omicron
  • Synonym symbol(s) PTPRU2, PTPRO2, hPTP-J, PCP-2, FMI, PTP, PTPPSI, PTPU2, GLEPP1, FLJ37530
    EC.number 3.1.3.48
    DNA
    TYPE functioning gene
    STRUCTURE 90.00 kb     31 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Physical map
    LOC339409 1p35.3 similar to Procollagen (type III) N-endopeptidase MGC34648 1p35.3 hypothetical protein MGC34648 STX12 1p35-p34.1 syntaxin 12 PPP1R8 1p35 protein phosphatase 1, regulatory (inhibitor) subunit 8 C1orf38 1p35.2 chromosome 1 open reading frame 38 RPA2 1p35 replication protein A2, 32kDa ASML3B 1p35.2 acid sphingomyelinase-like phosphodiesterase FLJ10307 1p35.2 hypothetical protein FLJ10307 EYA3 1p36 eyes absent homolog 3 (Drosophila) LOC388613 1 similar to Microsomal signal peptidase 25 kDa subunit (SPase 25 kDa subunit) (SPC25) LOC391024 1 similar to RIKEN cDNA 2610313E07 PTAFR 1p35.1-p34.3 platelet-activating factor receptor DNAJC8 1p35.3 DnaJ (Hsp40) homolog, subfamily C, member 8 ATPIF1 1p35.3 ATPase inhibitory factor 1 SESN2 1p35.3 sestrin 2 FLJ20045 1p35.2 TRAP/mediator complex subunit p28b FLJ13171 1p35 TRAP/mediator complex subunit p28b CHC1 1p36.1 chromosome condensation 1 SECP43 1p35.2 tRNA selenocysteine associated protein LOC85028 1p35.2 PNAS-123 MGC45806 1p35.2 hypothetical protein MGC45806 TAF12 1p35.2 TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa GMEB1 1p35.2 glucocorticoid modulatory element binding protein 1 HGRG8 14q12-q21 high-glucose-regulated protein 8 OPRD1 1p36.1-p34.3 opioid receptor, delta 1 EPB41 1p36.1-p35 erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked) LOC90719 1p35.2 similar to KIAA1913 SFRS4 1p35.1-p34.3 splicing factor, arginine/serine-rich 4 CGI-63 1pter-p22.3 nuclear receptor binding factor 1 PTPRU 1pter-p35 protein tyrosine phosphatase, receptor type, U LOC391025 1 similar to protein tyrosine phosphatase, receptor type, U isoform 2 precursor; protein tyrosine phosphatase J; protein tyrosine phosphatase receptor omicron; pi R-PTP-Psi LOC388614 1 LOC388614 LOC388615 1 LOC388615 MATN1 1p35.1-p34.3 matrilin 1, cartilage matrix protein LAPTM5 1p34 matrilin 1, cartilage matrix protein LOC388616 1 LOC388616
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 5579 161 1436 - Yan
    - - 5597 - 1442 - Yan
    - - 5609 162 1446 - Yan
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   highly
    Reproductivefemale systemovary  highly
     male systemtestis  highly
     male systemprostate  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a MAM domain, an Ig-like region,
  • four fibronectin FN III repeats
  • a transmembrane segment
  • two phosphatase domains with a large extracellular motif
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Ptpru (89 pc)
    Homologene
    FAMILY PTPR family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type I membrane protein
    basic FUNCTION tyrosine phosphatase, receptor
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS