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FLASH GENE
Symbol PTPRR contributors: mct - updated : 12-05-2010
HGNC name protein tyrosine phosphatase, receptor type, R
HGNC id 9680
Location 12q15      Physical location : 71.031.861 - 71.314.584
Synonym name
  • protein-tyrosine phosphatase NC-PTPCOM1
  • protein-tyrosine phosphatase PCPTP1
  • Ch-1 PTPase
    • Synonym symbol(s) DKFZp781C1038, EC-PTP, FLJ34328, MGC131968, MGC148170, PCPTP1, PTP-SL, PTPBR7
    EC.number 3.1.3.48
    DNA
    TYPE functioning gene
    STRUCTURE 282.72 kb     14 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 3492 - - - -
    10 - 2733 - 412 - -
    EXPRESSION
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal proteolytic processing, in between amino acid position 136 and 137
  • a tyrosine-protein phosphatase domain
    • HOMOLOGY
    Homologene
    FAMILY
  • protein-tyrosine phosphatase family
  • receptor class 7 subfamily
    • CATEGORY enzyme , receptor
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    ETV6/PTPRR in acute myelogenous leukemia with inv(12)(p13q13)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS