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FLASH GENE
Symbol PTPRR contributors: mct - updated : 12-05-2010
HGNC name protein tyrosine phosphatase, receptor type, R
HGNC id 9680
Location 12q15      Physical location : 71.031.861 - 71.314.584
Synonym name
  • protein-tyrosine phosphatase NC-PTPCOM1
  • protein-tyrosine phosphatase PCPTP1
  • Ch-1 PTPase
    • Synonym symbol(s) DKFZp781C1038, EC-PTP, FLJ34328, MGC131968, MGC148170, PCPTP1, PTP-SL, PTPBR7
    EC.number 3.1.3.48
    DNA
    TYPE functioning gene
    STRUCTURE 282.72 kb     14 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    IL22 12q15 interleukin 22 MDM1 12q14.3 nuclear protein double minute 1 LOC160410 12q14.3 proteasome (prosome, macropain) 26S subunit, ATPase, 6 pseudogene LOC387867 12 similar to 40S ribosomal protein SA (P40) (34/67 kDa laminin receptor) (Colon carcinoma laminin-binding protein) (NEM/1CHD4) (Multidrug resistance-associated protein MGr1-Ag) RAP1B 12q14 RAP1B, member of RAS oncogene family LOC246723 12q14 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d pseudogene NUP107 12q14.3 nuclear pore complex protein SLC35E3 12q15 solute carrier family 35, member E2 PRO2268 12q14.3 hypothetical protein PRO2268 MDM2 12q14.3-q15 Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) MGC5370 12q14.3 hypothetical protein MGC5370 CPM 12q15 carboxypeptidase M CPSF6 12q13.2 cleavage and polyadenylation specific factor 6, 68kDa LYZ 12q14-q15 lysozyme (renal amyloidosis) GAS41 12q13-q15 lysozyme (renal amyloidosis) FRS2 12q15 fibroblast growth factor receptor substrate 2 CCT2 12q15 chaperonin containing TCP1, subunit 2 (beta) LOC387868 12 similar to leucine-rich repeat-containing 10; leucine-rich repeat protein; leucine-rich containing 10 VMD2L3 12q14.2-q15 similar to leucine-rich repeat-containing 10; leucine-rich repeat protein; leucine-rich containing 10 MGC13168 12q14.3 hypothetical protein MGC13168 RAB3IP 12q13-q15 RAB3A interacting protein (rabin3) FLJ25056 12q14.3 hypothetical protein FLJ25056 CNOT2 12q13.2 CCR4-NOT transcription complex, subunit 2 KCNMB4 12q14.1-q15 potassium large conductance calcium-activated channel, subfamily M, beta member 4 LOC390342 12 similar to Gag-Pro-Pol-Env protein PTPRB 12q15 protein tyrosine phosphatase, receptor type, B PTPRR 12q13.2-q13.3 protein tyrosine phosphatase, receptor type, R TM4SF3 12q14.1-q21.1 transmembrane 4 superfamily member 3 GPR49 12q22-q23 G protein-coupled receptor 49 MGC23401 12q15 hypothetical protein MGC23401 DKFZP564I0422 12q15 hypothetical protein DKFZp564I0422 FLJ10936 12q15 hypothetical protein FLJ10936 RAB21 12q13.3 RAB21, member RAS oncogene family FLJ12085 TPH2 12q15 tryptophan hydroxylase 2 TRHDE 12q15-q21 Homo sapiens thyrotropin-releasing hormone degrading ectoenzyme (TRHDE), mRNA.
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 3492 - - - -
    10 - 2733 - 412 - -
    EXPRESSION
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal proteolytic processing, in between amino acid position 136 and 137
  • a tyrosine-protein phosphatase domain
    • HOMOLOGY
    Homologene
    FAMILY
  • protein-tyrosine phosphatase family
  • receptor class 7 subfamily
    • CATEGORY enzyme , receptor
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    ETV6/PTPRR in acute myelogenous leukemia with inv(12)(p13q13)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS