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FLASH GENE
Symbol PTPRE contributors: mct - updated : 28-10-2011
HGNC name protein tyrosine phosphatase, receptor type, E
HGNC id 9669
Location 10q26.2      Physical location : 129.705.324 - 129.884.162
Synonym name
  • protein tyrosine phosphatase epsilon
  • protein tyrosine phosphatase, receptor type, epsilon
  • Synonym symbol(s) PTPE, HPTPE, R-PTP-EPSILON
    EC.number 3.1.3.48
    DNA
    TYPE functioning gene
    STRUCTURE 178.86 kb     21 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Physical map
    ZRANB1 10q26.13 zinc finger, RAN-binding domain containing 1 CTBP2 21q21.3 C-terminal binding protein 2 MRPS21P6 10q26 mitochondrial ribosomal protein S21 pseudogene 6 LOC387718 10 hypothetical gene supported by AK131010; BC062717 LOC387719 10 LOC387719 EDRF1 10q26.2 erythroid differentiation-related factor 1 MMP21 10q26.3 matrix metalloproteinase 21 UROS 10q25.2-q26.3 uroporphyrinogen III synthase (congenital erythropoietic porphyria) BCCIP 10q26.1 BRCA2 and CDKN1A interacting protein DDX32 10q26.3 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 32 FANK1 10q26.2 fibronectin type 3 and ankyrin repeat domains 1 ADAM12 10q26.3 a disintegrin and metalloproteinase domain 12 (meltrin alpha) FLJ32938 10q26.2 hypothetical protein FLJ32938 DOCK1 10q26.13-q26.3 dedicator of cyto-kinesis 1 LOC387720 10 hypothetical gene supported by AK127642 LOC338623 10q26.2 similar to hypothetical protein B130055A05 MGC32871 10q26.3 hypothetical protein MGC32871 PTPRE 10q26 protein tyrosine phosphatase, receptor type, E MKI67 10q25-qter antigen identified by monoclonal antibody Ki-67 LOC387721 10 similar to bA442O18.2 (novel protein) MGMT 10q26 O-6-methylguanine-DNA methyltransferase LOC387722 10 LOC387722 FLJ11370 10q26.3 hypothetical protein FLJ11370 DKFZp667B0210 10q26.3 hypothetical protein DKFZp667B0210 LOC387723 10 LOC387723 TXNL2 6p25.3 thioredoxin-like 2
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    21 - 5392 - 700 - 2002 12861030
    possessing a short extracellular domain, a single transmembrane region, and two tandem intracytoplasmic catalytic domains
    18 - 5039 - 642 - 2002 12861030
    containing a distinct hydrophilic N-terminus, and thus representing a nonreceptor-type isoform
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon  
    Endocrinethyroid   highly
    Lymphoid/Immunelymph node    
     spleen   highly
    Nervousbrain    
    Reproductivemale systemtestis   
    Respiratoryrespiratory tractlarynx  highly
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two protein-tyrosine phosphatase domains
  • a unique 132-residue long C-terminal end with no known motifs or homology to other characterized proteins
  • HOMOLOGY
    Homologene
    FAMILY protein-tyrosine phosphatase family, receptor class 4 subfamily
    CATEGORY receptor membrane G phosphatase
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytoskeleton,intermed filament
    intracellular,nucleus
    basic FUNCTION
  • playing a regulatory role in RAS related signal transduction pathways, cytokines induced SATA signaling, as well as the activation of voltage-gated K+ channels
  • inhibiting the mitogen-activated protein kinase cascade through the extracellular signal-regulated kinase 1 and 2 pathway
  • negatively regulates potentially the development of atherosclerosis by activating SRC
  • negatively regulates FCER1A-mediated signalling pathways and thus constitutes a novel target for ameliorating allergic conditions
  • negatively regulates PDGFRB-mediated signaling pathways that are crucial for the pathogenesis of atherosclerosis, and may be involved in diabetes-accelerated atherosclerosis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS