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FLASH GENE
Symbol PTPRA contributors: mct - updated : 25-10-2016
HGNC name protein tyrosine phosphatase, receptor type, A
HGNC id 9664
Location 20p13      Physical location : 2.844.840 - 3.019.314
Synonym name
  • receptor-type tyrosine-protein phosphatase alpha
  • leukocyte common antigen-related peptide (protein tyrosine phosphate)
  • PTPLCA-related phosphatase
  • Synonym symbol(s) PTPA, PTPRL2, LRP, HLPR, HPTPA, RPTPA
    EC.number 3.1.3.48
    DNA
    TYPE functioning gene
    STRUCTURE 174.47 kb     34 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Physical map
    TGM6 20p13 transglutaminase y SNRPB 20p13 small nuclear ribonucleoprotein polypeptides B and B1 MGC10715 20p13 novel C2H2 type zinc finger protein TMC2 20p13 transmembrane, cochlear expressed, 2 NOL5A 20p13 nucleolar protein 5A (56kDa with KKE/D repeat) IDH3B 20p13 isocitrate dehydrogenase 3 (NAD+) beta KIAA1442 20p13 KIAA1442 protein RPL19P1 20p13 ribosomal protein L19 pseudogene 1 CPXM 20p12.3-p13 carboxypeptidase X (M14 family) C20orf141 20p13 chromosome 20 open reading frame 141 LOC388781 20 similar to RIKEN cDNA 4933425O20 C20orf81 20p13 chromosome 20 open reading frame 81 VPS16 20p13-p12 vacuolar protein sorting 16 (yeast) PTPRA 20p13 protein tyrosine phosphatase, receptor type, A GNRH2 20p13 gonadotropin-releasing hormone 2 MRPS26 20p13 mitochondrial ribosomal protein S26 OXT 20p13 oxytocin, prepro- (neurophysin I) AVP 20p13 arginine vasopressin (neurophysin II, antidiuretic hormone, diabetes insipidus, neurohypophyseal) UBCE7IP5 20p13 likely ortholog of mouse ubiquitin conjugating enzyme 7 interacting protein 5 FLJ13149 20p13 hypothetical protein FLJ13149 ProSAPiP1 20p13 ProSAPiP1 protein C20orf116 20p13 chromosome 20 open reading frame 116 ITPA 20p inosine triphosphatase (nucleoside triphosphate pyrophosphatase) SLC4A11 20p12 solute carrier family 4, sodium bicarbonate transporter-like, member 11 C20orf194 20p13 chromosome 20 open reading frame 194
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    34 - 3637 90 802 - 2011 21725282
    23 - 3328 - 793 - 2011 21725282
    - - - - - in colon, breast, and liver tumours 2011 21725282
  • its expression in the tumours correlated with SRC tyrosine dephosphorylation
  • 23 - 3153 - 793 - 2011 21725282
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • protein-tyrosine phosphatase family
  • receptor class 4 subfamily
  • CATEGORY enzyme , receptor membrane
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    text
  • significant fraction of PTPRA is present in lipid rafts, where its targets FYN
  • basic FUNCTION
  • tyrosine phosphatase, receptor
  • required for rigidity-dependent reinforcement of fibronectin (FN)-cytoskeleton bonds and the rigidity response in hippocampal neuron growth cones, like in fibroblasts
  • is a critical regulator of FYN activation and of specific FYN signaling events during differentiation, and is essential for promoting oligodendrocyte progenitor cells differentiation and central nervous system myelination
  • force-responsive proteins such as PTPRA can influence cancer-cell behavior and identify potential targets for cancer therapy
  • mitotic activator of the protein tyrosine kinase SRC
  • PTPRA acts in oligodendrocyte progenitor cells (OPCs) to limit self-renewal and facilitate differentiation
  • PTPRA functions as a master coordinator of both arms of the spatial two-pronged anchoring of PTPR1 in focal adhesions
  • may be involved in the formation of axoglial junctions and ensheathment in small axons during myelination of the spinal cord
  • PTPRA promotes profibrotic signaling pathways in fibroblasts through control of cellular responsiveness to TGFB1
  • is recruited to epithelial adherens junctions at the time of cell-cell contact, where it is in molecular proximity to CDH1
  • controls cadherin-mediated signaling by linking homophilic CDH1 engagement to cortactin tyrosine phosphorylation through SRC
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NCAM1 directly interacts with the intracellular domain of the receptor-like protein tyrosine phosphatase PTPRA, a known activator of FYN
  • PTPRA-induced phosphorylation of Paxillin and PAG1 induces recruitment of the SFK inhibitory kinase CSK, indicative of negative feedback loops limiting SFK activation by PTPRA
  • is an important positive regulator of FYN activation and signaling that is required for the differentiation of oligodendrocyte progenitor cells (OPCs)
  • GRB2 binding to PTPRA, which was proposed to compete with SRC binding to PTPRA, was only modestly reduced in mitosis, which could not account for enhanced SRC binding
  • PTPRA interacts with CNTN1 to form a membrane-spanning co-receptor complex to transduce extracellular signals to FYN tyrosine kinase
  • GRB2 is a new PTK2 activator awith an essential role in coordinating PTPRA tyrosine phosphorylation to enable downstream integrin signaling and migration
  • is a GNB2L1 binding protein, suggesting that GNB2L1 may coordinate PTPRA-Tyr-789 phosphorylation in the signaling networks to promote cell migration
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    facilitates abnormal myelination and pronouncedly increases the number of non-landed oligodendrocyte loops at shortened paranodes in the spinal cord
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Ptpra(-/-) mice were protected from pulmonary fibrosis induced by adenoviral-mediated expression of active TGFbeta1
  • PTPalpha(-/-) mice have more oligodendrocyte lineage cells in embryonic forebrain and delayed oligodendrocyte progenitor cells (OPCs) maturation