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FLASH GENE
Symbol PTPN9 contributors: SGE/npt - updated : 22-06-2010
HGNC name protein tyrosine phosphatase, non-receptor type 9
HGNC id 9661
Location 15q24.2      Physical location : 75.759.462 - 75.871.625
Synonym name
  • PTPase-MEG2
  • protein-tyrosine phosphatase MEG2
  • Synonym symbol(s) MEG2, PTPMEG2
    EC.number 3.1.3.48
    DNA
    TYPE functioning gene
    STRUCTURE 112.16 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    MGC14421 DRIL2 15q24 electron-transfer-flavoprotein, alpha polypeptide (glutaric aciduria II) CLK3 15q24 CDC-like kinase 3 FLJ21128 15q23 hypothetical protein FLJ21128 CYP1A1 15q22-q24 cytochrome P450, family 1, subfamily A, polypeptide 1 CYP1A2 15q22-q24 cytochrome P450, family 1, subfamily A, polypeptide 2 CSK 15q23-q25 c-src tyrosine kinase LMAN1L 15q22-23 lectin, mannose-binding, 1 like DKFZP434C131 15q23 DKFZP434C131 protein SCAMP2 15q23-q25 secretory carrier membrane protein 2 MPI 15q22-qter mannose phosphate isomerase FLJ00005 COX5A 15q25 cytochrome c oxidase subunit Va Rpp25 15q23 RNase P protein subunit p25 SCAMP5 15q22.33 RNase P protein subunit p25 MDS018 15q23 hypothetical protein MDS018 LOC390605 15 similar to stromal cell-derived factor 2 precursor DKFZP434H132 15q23 DKFZP434H132 protein LOC390606 15 similar to nucleolar phosphoprotein Nopp34 LOC388136 15 LOC388136 LOC388137 15 similar to Golgi autoantigen, golgin subfamily A member 6 (Golgin linked to PML) (Golgin-like protein) LOC390607 15 similar to Dynamin-1 (D100) (Dynamin, brain) (B-dynamin) LOC145801 15q23 similar to Acidic leucine-rich nuclear phosphoprotein 32 family member B (PHAPI2 protein) (Silver-stainable protein SSP29) (Acidic protein rich in leucines) FLJ20452 15q23 hypothetical protein FLJ20452 NEIL1 15q23 nei endonuclease VIII-like 1 (E. coli) MAN2C1 15q11-q13 mannosidase, alpha, class 2C, member 1 SIN3A 15q24 SIN3 homolog A, transcriptional regulator (yeast) PTPN9 15q22.33 protein tyrosine phosphatase, non-receptor type 9 RNUT1 15q22.33 RNA, U transporter 1 C15orf12 15q24 chromosome 15 open reading frame 12 MGC32065 15q23 hypothetical protein MGC32065 CSPG4 15q23 chondroitin sulfate proteoglycan 4 (melanoma-associated) MGC48986 15q23 hypothetical protein MGC48986 LOC388138 15 similar to Dynamin-1 (D100) (Dynamin, brain) (B-dynamin) LOC390608 15 similar to peptidyl-Pro cis trans isomerase LOC390609 15 similar to Golgi autoantigen, golgin subfamily A member 6 (Golgin linked to PML) (Golgin-like protein) LOC92912 15q23 hypothetical protein LOC92912 FBXO22 15q24.1 F-box only protein 22 LOC145957 15q23 neuregulin 4 FLJ38190 15q23-q24.1 hypothetical protein FLJ38190 ETFA 15q23-q25 electron-transfer-flavoprotein, alpha polypeptide (glutaric aciduria II) ISL2 15q23 ISL2 transcription factor, LIM/homeodomain, (islet-2)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 3956 - 593 - Gu (1992)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one CRAL-TRIO domain
  • one tyrosine-protein phosphatase domain
  • HOMOLOGY
    interspecies homolog to murine Ptpn9 (97.3pc)
    homolog to rattus Ptpn9 (97.1pc)
    Homologene
    FAMILY
  • protein tyrosine phosphatase family
  • non-receptor class 3 subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    text
  • cytoplasmic face of the enclosing membrane of secretory vesicles (Saito 2007)
  • basic FUNCTION
  • could participate in the transfert of hydrophobic ligands or in functions of the Golgi apparatus
  • may be involved in signaling events regulating phagocytosis
  • negatively regulating ERBB2 and EGFR signaling in breast cancer cells and inhibiting STAT activation (Yuan 2010)
  • mediator of blood glucose homeostasis through antagonsim of insulin signaling (Cho 2006)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by polyphosphoinositide
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
  • modulation of PTPN9 activity may be an effective strategy in the treatment of type 2 diabetes (Cho 2006)
  • ANIMAL & CELL MODELS