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FLASH GENE
Symbol PTPN9 contributors: SGE/npt - updated : 22-06-2010
HGNC name protein tyrosine phosphatase, non-receptor type 9
HGNC id 9661
Location 15q24.2      Physical location : 75.759.462 - 75.871.625
Synonym name
  • PTPase-MEG2
  • protein-tyrosine phosphatase MEG2
  • Synonym symbol(s) MEG2, PTPMEG2
    EC.number 3.1.3.48
    DNA
    TYPE functioning gene
    STRUCTURE 112.16 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 3956 - 593 - Gu (1992)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one CRAL-TRIO domain
  • one tyrosine-protein phosphatase domain
  • HOMOLOGY
    interspecies homolog to murine Ptpn9 (97.3pc)
    homolog to rattus Ptpn9 (97.1pc)
    Homologene
    FAMILY
  • protein tyrosine phosphatase family
  • non-receptor class 3 subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    text
  • cytoplasmic face of the enclosing membrane of secretory vesicles (Saito 2007)
  • basic FUNCTION
  • could participate in the transfert of hydrophobic ligands or in functions of the Golgi apparatus
  • may be involved in signaling events regulating phagocytosis
  • negatively regulating ERBB2 and EGFR signaling in breast cancer cells and inhibiting STAT activation (Yuan 2010)
  • mediator of blood glucose homeostasis through antagonsim of insulin signaling (Cho 2006)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by polyphosphoinositide
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
  • modulation of PTPN9 activity may be an effective strategy in the treatment of type 2 diabetes (Cho 2006)
  • ANIMAL & CELL MODELS