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FLASH GENE
Symbol PTPN5 contributors: mct - updated : 26-06-2013
HGNC name protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)
HGNC id 9657
Location 11 p15.1      Physical location : 18.749.477 - 18.813.389
Synonym name
  • STriatal-Enriched protein tyrosine Phosphatase
  • Synonym symbol(s) STEP, FLJ14427, PTPSTEP
    EC.number 3.1.3.48
    DNA
    TYPE functioning gene
    STRUCTURE 63.91 kb     15 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 3201 - 565 - 1998 9857190
    15 - 3156 - 565 - 1998 9857190
    15 - 3105 - 533 - 1998 9857190
    - - 3939 - 533 - 1998 9857190
    - - 3068 - 541 - 1998 9857190
    - - 2972 - 509 - 1998 9857190
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node    
    Nervousbrain     Homo sapiens
     brainbasal nucleistriatum  
    Reproductivefemale systemovary   
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentral   
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • putative SH3 domains
  • a tyrosine-protein phosphatase domain
  • HOMOLOGY
    interspecies homolog to murine striatum enriched phosphatase
    Homologene
    FAMILY protein-tyrosine phosphatase family, non-receptor class subfamily
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • regulating the activation of the extracellular signal-regulated kinases ERK1 and ERK2 by association through a kinase interaction motif
  • critical role in the outcomes of ischemic brain injury
  • may play a role in normal cognitive functioning and contribute to aspects of the neuropathology of schizophrenia
  • modulates neurotransmission by dephosphorylating regulatory tyrosine residues on its substrates
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • acts in the central nervous system to dephosphorylate a number of important proteins involved in synaptic function including ERK and NMDA receptor subunits
  • PTK2B is a substrate of striatal-enriched protein-tyrosine phosphatase (PTPN5)
  • APP regulates striatal-enriched protein tyrosine phosphatase (STEP) (PTPN5)
  • inactivates extracellular-signal-regulated kinase 1/2 (ERK1/2), limiting the duration and spatial distribution of ERK signaling
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    is associated with higher seizure thresholds
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    neurologyneurodegenerative 
    as a target for pharmacological treatment aimed at improving the formation of long-term memories
    neurologyneurodegenerativealzheimer
    modulating PTPN5 levels or inhibiting its activity may have beneficial effects for patients with AD
    neurologyneurodegenerativehuntington chorea
    increased STEP and calpain activation contribute to altered NMDAR localization in an HD mouse model, suggesting new therapeutic targets for HD
    ANIMAL & CELL MODELS
  • Step KO mice also display augmented fear conditioning as measured by an enhancement in conditioned suppression of instrumental response when a fear-associated conditioned stimulus was presented
  • significantly fewer Step knockout mice developed seizures that progressed to the stage of status epilepticus compared to WT mice