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FLASH GENE
Symbol PTPN4 contributors: mct/npt/pgu - updated : 22/10/2008
HGNC name protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
HGNC id 9656
Location 2q14.2      Physical location : 120.517.206 - 120.735.037
Synonym name
  • megakaryocyte phophatase
  • protein tyrosine phosphatase MEG1
  • PTPase-MEG1
  • Synonym symbol(s) PTPMEG, PTPMEG1, MEG, PTPase-MEG1
    EC.number 3.1.3.48
    DNA
    TYPE functioning gene
    STRUCTURE 217.83 kb     27 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    DDX18 2q13 DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 LOC389024 2 LOC389024 LOC343958 2q14.2 similar to 5-HT5B serotonin receptor FLJ10996 2q14.2 hypothetical protein FLJ10996 INSIG2 2q21.2 insulin induced gene 2 LOC389025 2 LOC389025 LOC151154 2q14.2 hypothetical LOC151154 EN1 2q14.2 engrailed homolog 1 MARCO 2q14.2 macrophage receptor with collagenous structure LOC165257 2q14.2 C1q-domain containing protein TSAP6 2q14.2 C1q-domain containing protein LOC389026 2 similar to PRO1546 DBI 2q12-q21 diazepam binding inhibitor (GABA receptor modulator, acyl-Coenzyme A binding protein) PR1 2q14.2 voltage-dependent calcium channel gamma subunit-like protein SCTR 2q14.1 secretin receptor LOC200373 2q14.2 similar to hypothetical protein MGC10993 2q14.2 hypothetical protein MGC10993 PTPN4 2p24.3-p24.1 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte) EPB41L5 2q21.2 erythrocyte membrane protein band 4.1 like 5 LOC391431 2 similar to NADH dehydrogenase subunit 5 FAM11B 2q21.2 similar to NADH dehydrogenase subunit 5 RALB 2cen-q13 v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein) INHBB 2q12-q13 inhibin, beta B (activin AB beta polypeptide) FLJ14816 2q14.2 hypothetical protein FLJ14816 GLI2 2q24 GLI-Kruppel family member GLI2 TFCP2L1 2q14 transcription factor CP2-like 1 CLASP1 2q14-q21 cytoplasmic linker associated protein 1 MKI67IP 2q14.3 MKI67 (FHA domain) interacting nucleolar phosphoprotein TSN 2q21.1 translin LOC389027 2 LOC389027 LOC389028 2 LOC389028
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    27 splicing 3963 105.8 926 - 2000 11054567
    - splicing 3200 - - testis (spermatocytes, spermatids) 2000 11054567
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineadrenal gland   predominantly
    Lymphoid/Immunespleen   highly
     thymus   highly
     tonsils   moderately
    Nervousbrainhindbraincerebellum  
    Reproductivemale systemtestis  moderately
    Respiratoryrespiratory tractlarynx  moderately
     respiratory tracttrachea  moderately
    cells
    SystemCellPubmedSpeciesStageRna symbol
    NervousPurkinje cell
    cell lineage
    cell lines
    fluid/secretion moderately in lymph
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a PTP domain, with FERM (Band 4.1, Ezrin, Radixin, and Moesin) domain
  • a PDZ domain dual specificity phosphatase catalytic domain
  • tyrosine-protein phosphatase domain
  • HOMOLOGY
    interspecies homolog to rattus Ptpn4 (95.6 pc)
    homolog to murine Ptpn4 (94.7 pc)
    intraspecies homolog to erythrocyte protein 4.1
    Homologene
    FAMILY
  • protein-tyrosine phosphatase family
  • non-receptor class subfamily
  • PTPH1-family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton
    text
  • extrinsic to membrane
  • located at the cytoplasmic face of the plasma membrane
  • basic FUNCTION
  • involved in the junctions between the membrane and the cytoskeleton
  • capable of dephosphorylating the TCR ITAMs and regulating NF-kappaB, and is dispensable for T cell development and/or T cell effector functions
  • with PTPN3 are dispensable for TCR signal transduction
  • regulating tyrosine dephosphorylation (important for both motor learning and cerebellar synaptic plasticity)
  • having a a regulatory role in T cell activation
  • may be involved in regulation of the membrane cytoskeleton, signal transduction, or both
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS