Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PTPN3 contributors: mct/npt - updated : 20-01-2010
HGNC name protein tyrosine phosphatase, non-receptor type 3
HGNC id 9655
Location 9q31.3      Physical location : 112.137.973 - 112.260.593
Synonym name
  • protein tyrosin phosphatase H1
  • cytoskeletal-associated protein tyrosine phosphatase
  • Synonym symbol(s) PTPH1, DKFZp686N0569
    EC.number 3.1.3.48
    DNA
    TYPE functioning gene
    STRUCTURE 122.62 kb     25 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Map cen - D9S53 - D9S172 - D9S748 - D9S310 - D9S309 - D9S58 - PTPN3 - D9S160 - D9S311 - D9S261 - D9S105 - D9S131 , D9S106 , D9S747 - D9S279 , D9S174 , D9S262 , D9S289 - qter
    Authors Slaugenhaupt (95)
    Physical map
    ZNF462 9q32 zinc finger protein 462 LOC389782 9 LOC389782 RAD23B 9q31.2 RAD23 homolog B (S. cerevisiae) KLF4 9q31 Kruppel-like factor 4 (gut) LOC392380 9 similar to peptidylprolyl isomerase A (cyclophilin A) LOC392381 9 similar to large subunit ribosomal protein L36a LOC392382 9 similar to ribosomal protein L31 LOC347292 9q32 similar to ribosomal protein L36; 60S ribosomal protein L36 IKBKAP 9q31 inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein ACTL7B 9q31 actin-like 7B ACTL7A 9q31 actin-like 7A FLJ20457 9q32 hypothetical protein FLJ20457 CTNNAL1 9q31.2 catenin (cadherin-associated protein), alpha-like 1 C9orf5 9q31 chromosome 9 open reading frame 5 EPB41L4B 9q22.1-q22.3 erythrocyte membrane protein band 4.1 like 4B FLJ21596 9q32 hypothetical protein FLJ21596 PTPN3 9q31.2 protein tyrosine phosphatase, non-receptor type 3 LOC347295 9q32 similar to DNA-binding protein B LOC389783 9 LOC389783 AKAP2 9q31-q33 a kinase (PRKA) anchor protein 2 PALM2 9q31-q33 paralemmin 2 TXN 9q31 thioredoxin LOC255220 9q32 similar to RIKEN cDNA 4930429J24 MUSK 9q31.3-q32 muscle, skeletal, receptor tyrosine kinase EDG2 9q31.3-q32 endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2 OR2K2 9q32 olfactory receptor, family 2, subfamily K, member 2 OR2AR1P 3p24.1 olfactory receptor, family 2, subfamily AR, member 1 pseudogene KIAA0368 9q22.3-q32 olfactory receptor, family 2, subfamily AR, member 1 pseudogene ZNF483 9 zinc finger protein 483 LTB4DH 9q32 leukotriene B4 12-hydroxydehydrogenase LOC392383 9 similar to hypothetical protein FLJ10120 GNG10 9q31-q32 guanine nucleotide binding protein (G protein), gamma 10 FLJ32779
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    20 - 8648 - 737 - Arimura (1992)
    21 - 8783 - 782 - Arimura (1992)
    25 - 6599 - 868 - Arimura (1992)
    16 - 6217 - 626 - Arimura (1992)
    15 - 6082 - 581 - Arimura (1992)
    26 - 6734 - 913 - Arimura (1992)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinethyroid    
    Nervousbrainmidbrainsubstantia nigra  
     braindiencephalon   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal FERM (EPB41, ezrin, radixin, moesin) domain cysteine-rich, basic charged globular module
  • several (? four) PDZ (PSD95.disc large/ZO-1) domains
  • a catalytic domain in the extreme C terminal part
  • HOMOLOGY
    Homologene
    FAMILY
  • protein-tyrosine phosphatase family
  • non-receptor class subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    text located at the cytoplasmic face of the plasma membrane (Han 2000)
    basic FUNCTION
  • tyrosine-phosphatase,non receptor,responding and participating in reorganization of membrane-cytoplasmic interactions
  • with PTPN4 are dispensable for TCR signal transduction (Bauler 2008)
  • inhibits T cell activation by dephosphorylating membrane-associated targets involved in TCR signaling (Han 2000)
  • seems to play an important role in gastric cancer differentiation and the progression of malignancy (Wu 2006)
  • having a controlling role in modulating GHR signaling and systemic growth through insulin-like growth factor 1 secretion (Pilecka 2007)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting protein of SCN5A (Jespersen 2006)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral somatic mutation      
    in colorectal cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS