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FLASH GENE
Symbol PTPN23 contributors: mct/npt - updated : 27-04-2012
HGNC name protein tyrosine phosphatase, non-receptor type 23
HGNC id 14406
Location 3p21.31      Physical location : 47.422.490 - 47.454.931
Synonym name
  • HIS-domain protein tyrosine phosphatase
  • protein tyrosine phosphatase TD14
  • Synonym symbol(s) HD-PTP, KIAA1471, HDPTP, PTP-TD14, DKFZP564F0923
    EC.number 3.1.3.48
    DNA
    TYPE functioning gene
    STRUCTURE 32.44 kb     25 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC391533 3 similar to Vascular endothelial growth factor receptor 1 precursor (VEGFR-1) (Vascular permeability factor receptor) (Tyrosine-protein kinase receptor FLT) (Flt-1) (Tyrosine-protein kinase FRT) (Fms-like tyrosine kinase 1) CCR1 3p21.31 chemokine (C-C motif) receptor 1 CCR3 3p21.31 chemokine (C-C motif) receptor 3 LTF 3p21.31 lactotransferrin TMEM7 3p21.3 transmembrane protein 7 LRRC2 3p21.3 leucine-rich repeat-containing 2 TDGF1 3p21.31 teratocarcinoma-derived growth factor 1 FLJ36525 3p21.31 hypothetical protein LOC259173 TMIE 3p21 hypothetical protein LOC259173 TSP50 3p14-p12 testes-specific protease 50 TESSP5 3p21.31 testis serine protease 5 LOC391534 3 hypothetical gene supported by AK128390 TESSP2 3p21.31 testis serine protease 2 MYL3 3p21.3 myosin, light polypeptide 3, alkali; ventricular, skeletal, slow PTHR1 3p21.3 parathyroid hormone receptor 1 MGC23918 3p21.31 hypothetical protein MGC23918 KIAA0540 3p21.31 KIAA0540 protein LOC391535 3 similar to p75-like apoptosis-inducing death domain protein PLAIDD HYPB 3p21.2-q22.2 similar to p75-like apoptosis-inducing death domain protein PLAIDD MRP63P3 3p21.31 mitochondrial ribosomal protein 63 pseudogene 3 KIF9 3p21.31 kinesin family member 9 KIAA0795 3p21.31 kinesin family member 9 PTPN23 3p21.3 protein tyrosine phosphatase, non-receptor type 23 SCAP 3p24.3-p22.1 protein tyrosine phosphatase, non-receptor type 23 FLJ20211 3p21.31 hypothetical protein FLJ20211 CSPG5 3p21.3 chondroitin sulfate proteoglycan 5 (neuroglycan C) SMARCC1 3p23-p21 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 DHX30 3p31.31 DEAH (Asp-Glu-Ala-His) box polypeptide 30 MAP4 3p21.3 microtubule-associated protein 4 LOC391536 3 similar to 60S ribosomal protein L17 (L23) CDC25A 3p21.3 cell division cycle 25A CAMP 3p21.3 cathelicidin antimicrobial peptide SZF1 3p21 KRAB-zinc finger protein SZF1-1 MRPS18AP1 3p21.31 mitochondrial ribosomal protein S18A pseudogene 1 NME6 3p21.3 non-metastatic cells 6, protein expressed in (nucleoside-diphosphate kinase) LOC391537 3 similar to hypothetical protein PLXNB1 3p21.31 plexin B1 FLJ12436 3p21.31 hypothetical protein FLJ12436 HSPC016 3p21.31 hypothetical protein HSPC016 TREX1 3p21.3-p21.2 three prime repair exonuclease 1 SCOTIN 3p21.31 scotin PFKFB4 3p22-p21 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    25 - 5283 179 1636 - 2007 17959146
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node   highly
    Nervousnerve   highly
    Respiratoryrespiratory tractlarynx  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal domain similar to yeast BRO1, AIP1 and rhophilin
  • "Zn-hand" domain containing several SH3-binding motif
  • a tyrosine phosphatase domain
  • a C terminal PEST motif
  • HOMOLOGY
    interspecies homolog to rattus Ptp-td4
    ortholog to S. cerevisiae Bro1p
    Homologene
    FAMILY
  • protein-tyrosine phosphatase family
  • non-receptor class subfamily
  • CATEGORY enzyme , receptor membrane phosphatase
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic,vesicle
    intracellular,cytoplasm,cytoskeleton,microtubule
    intracellular,nucleus
    basic FUNCTION
  • having a role in modulating endothelial motility
  • contributes to the regulation of endothelial motility by modulating the tyrosine phosphorylation of PTK2
  • key regulator of endocytic trafficking in which ESCRT-III binding is important but not strictly essential
  • participates to the regulation of endothelial motility through its interactions with Src and PTK2
  • catalytically inactive protein tyrosine phosphatase
  • essential requirement for early stages of embryonic development
  • non-transmembrane protein tyrosine phosphatase which contributes to the signal transduction pathways involved in the regulation of cell migration and invasion
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds Focal Adhesion Kinase (PTK2), a crucial regulator of cell migration
  • binds CHMP4B via its Bro1 domain, and TSG101 via a central domain that contains two PS/TAP motifs and other proline-rich sequences
  • interaction of PTPN23 with two adapters of the GRB2 family, essential for numerous signaling pathways, suggesting that PTPN23 might be important for signaling through a plethora of receptors
  • evolutionarily conserved function of PTPN23-RAB4A in the regulation of endocytic trafficking, cell adhesion and migration
  • cell & other
    REGULATION
    Other differentially modulated by two angiogenic growth factors
    degraded by calpains in a calcium-dependent manner, resulting in the acquisition of a more aggressive phenotype in neoplastic cells
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    loss of PTPN23 may increase the activity of SRC and the phosphorylation status of the CDH1/CTNNB signaling complex to promote tumor growth and invasive behavior in breast cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS