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FLASH GENE
Symbol PTPN14 contributors: mct - updated : 24-09-2013
HGNC name protein tyrosine phosphatase, non-receptor type 14
HGNC id 9647
Location 1q41      Physical location : 214.522.039 - 214.725.024
Synonym name
  • cytoskeletal-associated protein tyrosine phosphatase
  • protein-tyrosine phosphatase pez
  • Synonym symbol(s) PEZ, PTP36, MGC126803
    EC.number 3.1.3.48
    DNA
    TYPE functioning gene
    STRUCTURE 193.63 kb     19 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    DKFZP434B168 1p36.13-q42.3 DKFZP434B168 protein RAMP 1q32.1-q32.2 DKFZP434B168 protein PPP2R5A 1q41 protein phosphatase 2, regulatory subunit B (B56), alpha isoform FLJ10874 1q32.3 hypothetical protein FLJ10874 SPUF 1q32.3 secreted protein of unknown function ATF3 1q32.3 activating transcription factor 3 FLJ32796 1q32.3 hypothetical protein FLJ32796 LOC388735 1 LOC388735 SNFT 1q32.3 Jun dimerization protein p21SNFT DC8 1q41 DKFZP566O1646 protein LOC388736 1 similar to ribosomal protein S5; 40S ribosomal protein S5 LOC149643 1q32.3 hypothetical LOC149643 FLVCR 1q32.1-q32.2 hypothetical LOC149643 FLJ12505 1q32.3 hypothetical protein FLJ12505 LOC90806 1q32.3 similar to RIKEN cDNA 2610307I21 RPS6KC1 1q41 ribosomal protein S6 kinase, 52kDa, polypeptide 1 LOC391161 1 similar to ribosomal protein L31 PROX1 1q32.2-q32.3 prospero-related homeobox 1 SMYD2 1q32.3 SET and MYND domain containing 2 PTPN14 1q32.2 protein tyrosine phosphatase, non-receptor type 14 CENPF 1q32-q41 centromere protein F, 350/400ka (mitosin) LOC391162 1 similar to Glyceraldehyde 3-phosphate dehydrogenase, liver (GAPDH) KCNK2 1q41 potassium channel, subfamily K, member 2 LOC391163 1 similar to Voltage-dependent anion-selective channel protein 1 (VDAC-1) (mVDAC1) (mVDAC5) (Outer mitochondrial membrane protein porin 1) (Plasmalemmal porin) KCTD3 1q41 potassium channel tetramerisation domain containing 3 LOC388737 1 similar to bA275K8.2 (novel protein with weak homology to human Usher syndrome type 2A and NGCAM-related cell adhesion molecule proteins and rat glomerular mesangial cell receptor protein-tyrosine phosphatase) LOC391164 1 similar to protein tyrosine phosphatase, receptor type, Q isoform 1 precursor; glomerular mesangial cell receptor protein-tyrosine phosphatase LOC200125 1q41 similar to laminin A-chain USH2A 1q41 Usher syndrome 2A (autosomal recessive, mild) MRPS18BP1 6q22.33 mitochondrial ribosomal protein S17 pseudogene 5 ESRRG 1q32 estrogen-related receptor gamma
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    19 - 13443 135.3 1187 - PMID: 10600535
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Endocrinepancreas   highly
    Reproductivefemale systembreast  highly
     female systemplacenta  highly
    Respiratorylung    
    Urinarykidney    
    Visualeyelens   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    Muscularstriatumskeletal highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal FERM (EPB41, ezrin, radixin, moesin) domain cysteine-rich
  • basic charged globular module
  • several (four) PDZ (PSD95/disc large /ZO-1) domains
  • a central poorly conserved linker region with proline-rich SH3-like motifs
  • an acidic polyglutamate domain
  • a PPXY domain for interaction with WWC1
  • a C-terminal phosphatase domain
  • HOMOLOGY
    Homologene
    FAMILY
  • protein-tyrosine phosphatase family
  • non-receptor class subfamily
  • CATEGORY enzyme , tumor suppressor
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,adherens
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton
    text accumulation of the protein at adherens junctions
    basic FUNCTION
  • signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation
  • regulates TGFbeta signaling
  • unique and conserved role in the regulation of lymphatic development in mammals and a nonconserved role in choanal development in humans
  • acts to suppress cell proliferation by promoting cell density-dependent cytoplasmic translocation of YAP1
  • potential regulatory role of PTPN14 in the Hippo pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • regulatory roles of WWC1 and PTPN14 in the Hippo pathway
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • potential interaction between PTPN14 and the vascular endothelial growth factor receptor 3 (VEGFR3), a receptor tyrosine kinase essential for lymphangiogenesis
  • interacts with yes-associated protein 1 (YAP1), a member of the hippo signaling pathway
  • PTPN14 and WWC1 can induce the LATS1 activation independently and cooperatively
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral somatic mutation      
    in colorectal cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS