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FLASH GENE

Symbol

PTPN14

contributors: mct - updated : 24-09-2013

HGNC name	protein tyrosine phosphatase, non-receptor type 14
HGNC id	9647

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	1q41      Physical location : 214.522.039 - 214.725.024
Synonym name	cytoskeletal-associated protein tyrosine phosphatase
	protein-tyrosine phosphatase pez
Synonym symbol(s)	PEZ, PTP36, MGC126803
EC.number	3.1.3.48

DNA

TYPE	functioning gene
STRUCTURE	193.63 kb     19 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_005401 19 - 13443 NP_005392 135.3 1187 - PMID: 10600535

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Endocrine pancreas       highly Reproductive female system breast     highly   female system placenta     highly Respiratory lung         Urinary kidney         Visual eye lens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone       Muscular striatum skeletal   highly

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a N terminal FERM (EPB41, ezrin, radixin, moesin) domain cysteine-rich
	basic charged globular module
	several (four) PDZ (PSD95/disc large /ZO-1) domains
	a central poorly conserved linker region with proline-rich SH3-like motifs
	an acidic polyglutamate domain
	a PPXY domain for interaction with WWC1
	a C-terminal phosphatase domain

HOMOLOGY

Homologene

FAMILY	protein-tyrosine phosphatase family
	non-receptor class subfamily

CATEGORY

enzyme , tumor suppressor

SUBCELLULAR LOCALIZATION	plasma membrane,junction,adherens
	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,cytoplasm,cytoskeleton
text	accumulation of the protein at adherens junctions

basic FUNCTION	signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation
	regulates TGFbeta signaling
	unique and conserved role in the regulation of lymphatic development in mammals and a nonconserved role in choanal development in humans
	acts to suppress cell proliferation by promoting cell density-dependent cytoplasmic translocation of YAP1
	potential regulatory role of PTPN14 in the Hippo pathway

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

regulatory roles of WWC1 and PTPN14 in the Hippo pathway

a component

INTERACTION

DNA

RNA

small molecule

protein	potential interaction between PTPN14 and the vascular endothelial growth factor receptor 3 (VEGFR3), a receptor tyrosine kinase essential for lymphangiogenesis
	interacts with yes-associated protein 1 (YAP1), a member of the hippo signaling pathway
	PTPN14 and WWC1 can induce the LATS1 activation independently and cooperatively

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral somatic mutation       in colorectal cancer

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS