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FLASH GENE
Symbol PTPN13 contributors: mct - updated : 06-10-2010
HGNC name protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
HGNC id 9646
Location 4q21.3      Physical location : 87.515.467 - 87.736.326
Synonym name
  • Fas associated protein tyrosine phosphatase 1
  • protein-tyrosine phosphatase 1, Fas-associated
  • protein tyrosine phosphatase, nonreceptor type 13
  • Synonym symbol(s) PNP1, FAP-1, PTP1E, PTPLE, PTP-BL, PTPL1, PTP-BAS, DKFZp686J1497
    EC.number 3.1.3.48
    DNA
    TYPE functioning gene
    SPECIAL FEATURE head to head
    text head to head orientation with MAPK10
    STRUCTURE 220.86 kb     48 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter (CAAT box)
    cytosine-phosphate-guanine/HTF
    text structure a bidirectional promoter region that appeared to contain multiple cis elements, including Sp1, AP-1, AP-2, GATA-1, a GC box, and a CCAAT box
    MAPPING cloned Y linked N status confirmed
    Physical map
    WDFY3 4q21.23 WD repeat and FYVE domain containing 3 LOC391675 4 LOC391675 DKFZP564B1162 4q22.1 hypothetical protein DKFZp564B1162 MAPK10 4q21-q22 mitogen-activated protein kinase 10 PTPN13 4q21.3 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) SOAT 4q22.1 sodium-dependent organic anion transporter MGC26744 4q22.1 hypothetical protein MGC26744 LOC260422 4q21.3 actin related protein 2/3 complex subunit 1A pseudogene LOC389210 4 similar to hypothetical protein LOC391676 4 similar to Synaptic glycoprotein SC2 MLLT2 4q21 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 2 KLHL8 4q22.1 kelch-like 8 (Drosophila) GAPDL4 4pter-p16.2 glyceraldehyde-3-phosphate dehydrogenase-like 4 SCDR9 4q22.1 short-chain dehydrogenase/reductase 9 DHRS8 4q22.1 dehydrogenase/reductase (SDR family) member 8 NUDT9 4q21.3 nudix (nucleoside diphosphate linked moiety X)-type motif 9 SPARCL1 4q27 SPARC-like 1 (mast9, hevin) DSPP 4q21.3 dentin sialophosphoprotein DMP1 4q21.2-q21.3 dentin matrix acidic phosphoprotein LOC391677 4 similar to chromosome 7 open reading frame 17 protein; 16.7kD protein IBSP 4q21-q25 integrin-binding sialoprotein (bone sialoprotein, bone sialoprotein II) MEPE 4q21.1 matrix, extracellular phosphoglycoprotein with ASARM motif (bone) HSPCP1 4q21-q25 heat shock 90kDa protein 1, beta pseudogene 1 SPP1 4q21-q25 secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1) PKD2 4q22 polycystic kidney disease 2 (autosomal dominant) ABCG2 4q22 ATP-binding cassette, sub-family G (WHITE), member 2 DKFZp761G058 4q22.1 hypothetical protein DKFZp761G058
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    48 polyA site 8573 276 2485 - 1994 8071359
    47 splicing 8516 274.9 2466 - 1994 8071359
    45 splicing 8000 255.9 2294 - 1994 8071359
    48 splicing 8588 277.5 2490 - 1994 8071359
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineneuroendocrinepituitary  highly
     pancreas   moderately
    Hearing/Equilibriumearinnercochlea highly
    Urinarykidney   highly
    Visualeye   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • the GLGF repeat and a leucine zipper domain
  • a membrane binding region, homologous to that found in cytoskeleton associated proteins, ezrin/moesin/radixin-like (ERM) family member
  • five PDZ/DHR domains
  • HOMOLOGY
    interspecies homolog to murine Ptpn13
    Homologene
    FAMILY
  • protein-tyrosine phosphatase family
  • non-receptor class subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    intracellular,nucleus
    basic FUNCTION
  • tyrosine phosphatase, non receptor, responding and participating in reorganization of membrane-cytoplasmic interactions
  • in association with PARG1, may function as a negative regulator of Rho signaling
  • plays a counteracting role in regulating TRIP6 function in lysophosphatidic acid (LPA)-induced cell migration
  • plays a wider role in modulating cell motility through dephosphorylation of other substrates involved in cell adhesion and migration
  • specifically dephosphorylates insulin receptor substrate-1 (IRS1), having a crucial role in IRS1 dephosphorylation
  • direct positive role of the putative tumor suppressor gene PTPN13 on apoptosis
  • IRF8-induced PTPN13 repression occurred in granulocyte/monocyte progenitor cells, and this activity increased during myeloid differentiation
  • PTPN13 is an IRF8 target gene
  • inhibits ERBB2 activity by dephosphorylating the signal domain of ERBB2 and plays a role in attenuating invasiveness and metastasis of ERBB2 overactive tumors
  • important regulatory element of breast tumor aggressiveness and sensitivity to treatments such as antiestrogens and antiaromatase
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PRKCL2 for regulation of the action cytoskeleton
  • the four most C-terminal amino acid residue of PARG1 interacts specifically with the fourth PDZ domain of PTNP13
  • transcriptional target of EWS-FLI1
  • target gene of IRF8 (interacted with a cis element in the proximal PTPN13 promoter and repressed transcription)
  • interaction with FAS results in FAS dephosphorylation and inhibition of FAS-induced apoptosis
  • interacting with PDLIM4 and SRC (PDLIM4 suppresses SRC activation through interacting with SRC and PTPN13, allowing PTPN13-dependent dephosphorylation of SRC at the activation loop)
  • PTPN13 is an IRF8 target (repression of PTPN13 by IRF8 requires cooperation with ETV6 and histone deacetylase 3)
  • VCP regulation by PTPN13 might be important for tumorigenesis
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in Ewing's Sarcoma family tumors, with metastasis
    tumoral somatic mutation      
    in colorectal cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS