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FLASH GENE
Symbol PTPN12 contributors: mct - updated : 26-06-2013
HGNC name protein tyrosine phosphatase, non-receptor type 12
HGNC id 9645
Location 7q11.23      Physical location : 77.166.772 - 77.269.388
Synonym name protein-tyrosine phosphatase G1
Synonym symbol(s) PTPG1, tcag7.1075, PTP-PEST, PEST
EC.number 3.1.3.48
DNA
TYPE functioning gene
STRUCTURE 102.62 kb     18 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
18 - 3240 88.1 780 - 2007 17329398
18 - 3122 - 661 - 2007 17329398
16 - 3026 - 650 - 2007 17329398
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivestomach    
Hearing/Equilibriumear   highly
Nervousnerve   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone  highly
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/ImmuneT cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
PEST sequences
HOMOLOGY
Homologene
FAMILY
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,cytosolic
basic FUNCTION
  • involved in the regulation of the actin cytoskeleton, and participates in the regulation of apoptosis
  • contributing to the cellular apoptotic response and reveal the importance of caspases as regulators of PTPs in apoptosis
  • playing a key role in in regulating WAS
  • actively contributes to the cellular apoptotic response and reveal the importance of caspases as regulators of PTPs in apoptosis
  • involved in the regulation of sealing ring formation in osteoclasts
  • required for secondary T cell responses, anergy prevention, and autoimmunity induction
  • its expression in endothelial cells is required for normal vascular development and embryonic viability
  • essential role in embryonic development and viability
  • protects cells against aberrant ROS accumulation and death induced by oxidative stress
  • having potentially ability to control phosphorylation of PTK2B and paxillin, thereby regulating cell polarization, migration, and spreading
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component part of a signaling complex with PTK2B, CSK, and LPXN to regulate migration of prostate cancer cells
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with Caspase-3 (specifically cleaved PTP-PEST at the (549)DSPD motif and generated fragments, some of which displayed increased catalytic activity)
  • interact with WAS via proline, serine, threonine phosphatase interacting protein (PSTPIP)1 binding
  • tempers T cell activation by dephosphorylating TCR-proximal signaling molecules, such as LCK
  • interaction with PXN (PXN interaction contributes to integrin signaling events associated with the spatiotemporal regulation of key modulators of the cytoskeleton and cell motility machinery)
  • regulatory role of PTPN12 on dephosphorylation of SRC at Y527 and phosphorylation at Y418 in the catalytic site
  • controls PTK2B activity and is a positive regulator of secondary T cell activation
  • suppresses transformation of breast cancer cells by interacting with and inhibiting multiple oncogenic tyrosine kinases, including ERBB2 and EGFR
  • involved with dynamin in dephosphorylation of PTK2B, which is critical for terminating outside-in integrin signaling, and for stabilizing cytoskeletal reorganization during osteoclast bone resorption
  • SKAP2 is a novel substrate of PTPN12
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral somatic mutation      
    aberrant transcripts in colon cancer cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    may represent a novel therapeutic targetin breast cancer
    ANIMAL & CELL MODELS