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FLASH GENE
Symbol PTP4A3 contributors: mct - updated : 19-09-2013
HGNC name protein tyrosine phosphatase type IVA, member 3
HGNC id 9636
Location 8q24.3      Physical location : 142.432.006 - 142.441.620
Synonym name
  • potentially prenylated protein tyrosine phosphatase
  • protein-tyrosine phosphatase of regenerating liver 3
  • protein-tyrosine phosphatase 4a32
  • Synonym symbol(s) PRL3, PRLR, PRL-3, PRL-R
    EC.number 3.1.3.48
    DNA
    TYPE functioning gene
    STRUCTURE 9.61 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    text structure
  • 5prime untranslanted region (UTR) of PTP4A3 mRNA possesses triple GCCCAG motifs capable of suppressing mRNA translation through interaction withPCBP1, which retards PTP4A3 mRNA transcript incorporation into polyribosomes
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 splicing 1321 - 148 - 2004 15135076
    5 splicing 1396 - 173 - 2004 15135076
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Endocrinepancreas   highly
    Nervousnerve   highly
    Reproductivemale systemprostate  moderately
    Respiratorylung   moderately
    Urinarykidney   moderately
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Muscularmyocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one PTP domain
  • one C terminal prenylation motif
  • HOMOLOGY
    interspecies homolog to murine ptp4a3
    intraspecies homolog to PRL1
    Homologene
    FAMILY
  • protein-tyrosine phosphatase family
  • CATEGORY regulatory , receptor membrane G tyrosine phosphatase
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • play regulatory roles in a variety of cellular processes
  • protein tyrosine phosphatase associated with tumor metastasis
  • promotes cancer metastasis through enhanced cell motility and invasiveness
  • is a novel regulator of NFKB1 signaling pathway through TERF2IP
  • PTP4A1, PTP4A2, PTP4A3 are key contributors to metastasis in several human cancers
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • down-regulate the tyrosine-phosphorylation level of integrin beta1 (ITGA1) and increased the phosphorylation level of Erk1/2
  • inverse correlation between protein levels of PTP4A3 and PCBP1 in human primary cancers
  • Stathmin, a key oncoprotein, is a new PTP4A3 associated protein (both contributed to microtubule (MT) destabilization of colorectal carcinoma cells)
  • FKBP8 is an interacting protein of PTP4A3
  • interacts with telomere-related protein TERF2IP
  • LEO1 is a novel and important mediator of PTP4A3 oncogenic activities in Acute Myeloid Leukemia (AML)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in colorectal tumor with metastases
    tumoral     --over  
    in various cancers, such as colorectal cancer, gastric cancer, and ovarian cancer, and is correlated with the progression and survival of cancers
    tumoral     --over  
    is a frequent event associated with lymph node metastasis (LNM) and plays a causative role in promoting cancer progression (
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancermetastases 
    may constitute a useful marker for metastasis and might be a new therapeutic target
    cancerdigestivecolon
    act as a promising biomarker for individualized therapy for patients with colonic cancer, especially for those diagnosed at an early stage.
    cancerdigestiveoesophagus
    could be a convergent therapeutic target against esophageal squamous cell carcinoma (ESCC) with lymph node metastasis (PMID: 19960436)
    ANIMAL & CELL MODELS