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FLASH GENE
Symbol PTP4A2 contributors: mct - updated : 28-12-2016
HGNC name protein tyrosine phosphatase type IVA, member 2
HGNC id 9635
Location 1p35.2      Physical location : 32.372.021 - 32.403.988
Synonym name
  • phosphatase of regenerating liver 2
  • Synonym symbol(s) HH13, HH72, OV-1, PRL2, PTP4A, PTP4A1, HU-PP-1, PTPCAAX2
    EC.number 3.1.3.48
    DNA
    TYPE functioning gene
    STRUCTURE 36.21 kb     6 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    HPRP8BP 1p35.1 U5 snRNP-specific 40 kDa protein (hPrp8-binding) PS1D 1p35.1 putative S1 RNA binding domain protein FABP3 1p33-p32 fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor) TDE2L 1p35.1 tumor differentially expressed 2-like LOC127572 1p35.1 similar to elongation factor 1 alpha LOC149086 1p35.1 hypothetical protein LOC149086 LCN7 1p34.3 lipocalin 7 HCRTR1 1p33 hypocretin (orexin) receptor 1 PEF 1p34 hypocretin (orexin) receptor 1 COL16A1 1p34.3 collagen, type XVI, alpha 1 BAI2 1p35 brain-specific angiogenesis inhibitor 2 FLJ25348 1p35.1 hypothetical protein FLJ25348 PTP4A2 1p36 protein tyrosine phosphatase type IVA, member 2 KHDRBS1 1p32 KH domain containing, RNA binding, signal transduction associated 1 FLJ10315 1p34.3 hypothetical protein FLJ10315 KPNA6 1p35-p34.1 karyopherin alpha 6 (importin alpha 7) DKFZp451J0118 1p34.3 taxilin MGC1203 1p36.11-p34.2 hypothetical protein MGC1203 FLJ10547 1p36.11-p34.2 hypothetical protein FLJ10547 RP4-622L5 1p36.11-p34.2 hypothetical protein RP4-622L5 EIF3S2 1p34.1 eukaryotic translation initiation factor 3, subunit 2 beta, 36kDa LOC339483 1p34.3 hypothetical protein LOC339483 MGC10820 1p34.3 hypothetical protein MGC10820 LCK 1p35.1 lymphocyte-specific protein tyrosine kinase HDAC1 1p34.3 histone deacetylase 1 MLP 1p34 MARCKS-like protein STK22C 1p34-p35 serine/threonine kinase 22C (spermiogenesis associated) FLJ10276 1p34.3 hypothetical protein FLJ10276 LOC343338 1p34.3 similar to Glyceraldehyde 3-phosphate dehydrogenase, liver (GAPDH)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 3939 - 167 - 2001 11447212
    4 - 3463 - 142 - 2001 11447212
    4 - 3445 - 135 - 2001 11447212
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Lymphoid/Immunelymph node   highly
    Nervousbrainlimbic systemhippocampus   Homo sapiens
    Urinarykidneytubulecollecting duct highly Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Muscularsmoothvessel   Homo sapiens
    Muscularstriatumcardiac   Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousependymal cell Homo sapiens
    Nervouspyramidal cell Homo sapiens
    Visualcone photoreceptor Homo sapiens
    Visualrod photoreceptor Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    protein tyrosine phosphatase, catalytic domain
    HOMOLOGY
    interspecies homolog to rattus Prl1(regenerattusing liver protein tyrosine phosphatase 1)
    homolog to murine Ptp4a2
    Homologene
    FAMILY protein tyrosine phosphatase 4A (PTP4A) family
    CATEGORY enzyme , protooncogene
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    intracellular,nucleus
    basic FUNCTION
  • tyrosine phosphatase, functioning as an oncogene in prostate cancer
  • promotes cell migration and invasion through an ERK-dependent signaling pathway
  • implicated in the control of cell proliferation and invasion
  • is required for extra-embryonic development
  • is likely required for spermatogenesis during testis development
  • PTP4A1, PTP4A2, PTP4A3 are key contributors to metastasis in several human cancers
  • pivotal role for PTP4A2 2 in regulating cellular magnesium homeostasis
  • oncogenic PTP4A2 controls tumor growth by modulating intracellular magnesium levels through binding with the CNNM3 magnesium transporter
  • plays critical roles in regulating hematopoietic stem cell (HSC) self-renewal and mediating stem cell factor (SCF)/KIT signaling
  • is involved in cell-type-specific Mg(2+) homeostasis and its expression is potentially inversely regulated by dietary Mg(2+) levels
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • increases EPO and IL3 responses in hematopoietic cells
  • promotes AKT1 activation by down-regulating PTEN through the proteasome pathway
  • promotes KIT-mediated PI3K/Akt signaling by reducing the level of PTEN that normally antagonizes the pathway
  • regulates intracellular magnesium levels by forming a functional heterodimer with the magnesium transporter CNNM3
  • modulates intracellular Mg(2+) levels and sustains cancer phenotypes by binding to the Mg(2+) transporter CNNM3
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in prostate cancer and in benign adenoma
    constitutional   deletion    
    leads to impaired placental development and retarded growth at both embryonic and adult stages
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • PTP4A2 mRNA expression alone may serve as a biomarker for prediction of a breast cancer patient risk of recurrence and overall survival
  • Therapy target
    SystemTypeDisorderPubmed
    cancer  
    ability of PTP4A2 to repress PTEN expression qualifies it as an oncogene and a novel target for developing anti-cancer agents
    ANIMAL & CELL MODELS
  • Prl2-deficient male mice exhibit testicular hypotrophy and impaired spermatogenesis, leading to decreased reproductive capacity