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FLASH GENE

Symbol

PTH2R

contributors: mct - updated : 21-01-2021

HGNC name	parathyroid hormone 2 receptor
HGNC id	9609

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	2q33      Physical location : 209.271.555 - 209.359.224
Synonym name	parathyroid hormone receptor 2
	PTH2 receptor
Synonym symbol(s)	PTHR2

DNA

TYPE	functioning gene
STRUCTURE	134.81 kb     13 Exon(s)

MAPPING

cloned

Y

linked

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001309516 13 - 2971 NP_001296445 - 439 - 2015 26044810 NM_001371905 14 - 3038 NP_001358834 - 439 - 2015 26044810 NM_001371906 14 - 3047 NP_001358835 - 439 - 2015 26044810 NM_001371907 10 - 2695 NP_001358836 - 347 - 2015 26044810 NM_005048 13 - 2752 NP_005039 62 550 - 2015 26044810

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive esophagus           mouth tongue       Endocrine pancreas         Nervous brain       predominantly Homo sapiens   brain forebrain       Homo sapiens Respiratory respiratory tract larynx

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic leukocyte Nervous neuron Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY	G protein coupled receptor superfamily
	parathyroid hormone (PTH) family of peptide hormones

CATEGORY

signaling hormone , receptor

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	coupling with Gs alpha protein and activating adenylate cyclase
	may be functioning as a neurotransmitter receptor
	involvement in regulation of fear, anxiety, reproductive behaviors, release of pituitary hormones, and nociception
	PTH2-PTH2R system involved in nociceptive information processing in the spinal cord, in the regulation of different hypophysiotropic neurons in the hypothalamus, and in the modulation of affective behaviors
	possible new central mechanism for endocannabinoid regulation, via PTH2 acting on the PTH2R in discrete brain regions
	role for PTH2R signaling in postnatal growth plate development and subsequent bone mass acquisition
	PTH2, via its receptor, the parathyroid hormone 2 receptor (PTH2R), modulates fear memory
	novel role for PTH2R signaling in extracellular matrix production

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

hormonal

a component

INTERACTION

DNA

RNA

small molecule

protein	receptor for parathyroid hormone (PTH)
	PTH2/PTH2R signaling inhibits proliferation and alters differentiation of chondrocytes by modulating SOX9 expression, thereby substantiating the functional significance of this signaling pathway in chondrocyte biology
	PTH2 acting via the PTH2R modulates several aspects of the stress response

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   in hyperparathyroidism constitutional       loss of function in non-syndromic craniosynostosis (CRS) (NSC) patients

Susceptibility

to familial early-onset generalized osteoarthritis

Variant & Polymorphism other	polymorphism associated to familial early-onset generalized osteoarthritis (minor role)

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS