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FLASH GENE

Symbol

PTGR1

contributors: npt/ - updated : 23-01-2008

HGNC name	prostaglandin reductase 1
HGNC id	18429

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	9q31.3      Physical location : 114.312.002 - 114.362.135
Synonym name	leukotriene B4 12-hydroxydehydrogenase
	zinc binding alcohol dehydrogenase domain containing 3
	15-oxoprostaglandin 13-reductase
Synonym symbol(s)	LTB4DH, ZADH3, MGC34943
EC.number	1.3.1.74,1.3.1.48

DNA

TYPE	functioning gene
STRUCTURE	36.46 kb     10 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed PTGR1 10 - 1257 35.75 329 - -

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine         intestine large intestine colon       liver         Nervous brain         Reproductive male system prostate       Urinary kidney

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a NADP binding site
	a C terminal proline rich motif

mono polymer

monomer

HOMOLOGY

Homologene

FAMILY

NADP-dependent oxidoreductase L4BD family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm

basic FUNCTION

catalysing the conversion of leukotriene B4 into its biologically less reactive metabolite 12-oxo-leukotriene B4, a key step for its inactivation

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

inflammation

PATHWAY

metabolism

lipid/lipoprotein

signaling

leukotriene

a component

INTERACTION

DNA

RNA

small molecule	metal binding, cofactor, nucleotide,
	NADP
	Zn2+

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS