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FLASH GENE
Symbol PTGFRN contributors: mct/pgu - updated : 17-03-2012
HGNC name prostaglandin F2 receptor negative regulator
HGNC id 9601
Location 1p13.1      Physical location : 117.452.688 - 117.532.972
Synonym name
  • CD9 partner 1
  • Glu-Trp-Ile EWI motif-containing protein F
    • Synonym symbol(s) CD315, CD9P-1, EWI-F, FLJ11001, FPRP, KIAA1436, SMAP-6
    DNA
    TYPE functioning gene
    STRUCTURE 80.28 kb     9 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    AMPD1 1p13 adenosine monophosphate deaminase 1 (isoform M) NRAS 1p13.2 neuroblastoma RAS viral (v-ras) oncogene homolog D1S155E 1p22 NRAS-related gene FLJ21168 1p13.1 hypothetical protein FLJ21168 SYCP1 1p13 synaptonemal complex protein 1 TSHB 1p13 thyroid stimulating hormone, beta TSPAN-2 1p13.1 tetraspan 2 NGFB 1p13.1 nerve growth factor, beta polypeptide LOC391068 1 similar to mCAF1 protein VANGL1 1p11-p13.1 vang-like 1 (van gogh, Drosophila) LOC387624 1 hypothetical gene supported by NM_024062 CASQ2 1p13.3-p11 calsequestrin 2 (cardiac muscle) NHLH2 1p12-p11 nescient helix loop helix 2 LOC343019 1p12 similar to Hnrpa1 protein SLC22A15 1p12 solute carrier family 22 (organic cation transporter), member 15 FLJ38716 1p12 hypothetical protein FLJ38716 ATP1A1 1p13 ATPase, Na+/K+ transporting, alpha 1 polypeptide MGC16179 1p12 hypothetical protein MGC16179 LOC148766 1p12 hypothetical LOC148766 CD58 1p13 CD58 antigen, (lymphocyte function-associated antigen 3) IGSF3 1p13 immunoglobulin superfamily, member 3 LOC388667 1 LOC388667 LOC391069 1 similar to Glyceraldehyde 3-phosphate dehydrogenase, liver (GAPDH) LOC339396 1p12 similar to neurofilament, heavy polypeptide 200kDa; Neurofilament, heavy polypeptide; neurofilament, heavy polypeptide (200kD) CD2 1p13.1 CD2 antigen (p50), sheep red blood cell receptor PTGFRN 1p13.1-q21.3 prostaglandin F2 receptor negative regulator IGSF2 1p13 immunoglobulin superfamily, member 2 TTF2 1p13.1 transcription termination factor, RNA polymerase II TRIM45 1q12-21 tripartite motif-containing 45 LOC391070 1 similar to 40S ribosomal protein S15a B7-H4 1p12 immune costimulatory protein B7-H4 MAN1A2 1p13.1 mannosidase, alpha, class 1A, member 2 FLJ20202 1p12 FLJ20202 protein LOC391071 1 similar to voltage-dependent anion channel 2 GDAP2 1q21.1 ganglioside induced differentiation associated protein 2 WDR3 1p13-p12 WD repeat domain 3 LOC391072 1 similar to protease (prosome, macropain) 26S subunit, ATPase 1 LOC343492 1p12 similar to Vigilin (High density lipoprotein-binding protein) (HDL-binding protein) TBX15 1p13 T-box 15 WARS2 1p13.3-p13.1 tryptophanyl tRNA synthetase 2 (mitochondrial)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 6160 - 879 - -
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestivemouthtongue  highly
     stomach   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • 6 Ig-like C2-type (immunoglobulin-like) domains
  • a cytoplasmic tail, with a stretch of basic charged AAs that may act as binding sites for actin-linking ezrin-radixin-moesin (ERM) proteins
  • its cytoplasmic region contains potential calmodulin-dependent protein kinase phosphorylation sites and protein kinase C phosphorylation sites
    • HOMOLOGY
    Homologene
    FAMILY immunoglobulin (Ig) superfamily protein
    CATEGORY immunity/defense , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    text colocalized with ERM proteins at microspikes and microvilli of adherent cells and at the cellular uropod in polarized migrating leukocytes
    basic FUNCTION
  • prostaglandin F2 alpha receptor (FP), negative receptor
  • inhibiting the binding of prostaglandin F2-alpha (PGF2- alpha) to its specific FP receptor
  • through their direct interaction with ERM proteins, act as linkers to connect tetraspanin-associated microdomains to actin cytoskeleton regulating cell motility and polarity
  • self-associates independently from its association with tetraspanins, and tetraspanins can play a role on PDGFRN oligomerization status
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • IFITM5 forms a complex with FKBP11-CD81-PTGFRN
  • major component of the tetraspanin web, a network of molecular interactions in the plasma membrane, in which it specifically associates with tetraspanins CD9 and CD81
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • direct partner of tetraspanins CD9 (Tspan29) and CD81 (Tspan28)
  • CD81 associated with PTGFRN
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS