Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PTGES3 contributors: mct - updated : 22-08-2014
HGNC name prostaglandin E synthase 3 (cytosolic)
HGNC id 16049
Location 12q13.3      Physical location : 57.057.126 - 57.082.078
Synonym name unactive progesterone receptor, 23 kD
Synonym symbol(s) P23, TEBP, cPGES
DNA
TYPE functioning gene
STRUCTURE 24.96 kb     8 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 1932 - 160 - 2011 21183720
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon moderately
 liver   highly
 pancreas exocrine   moderately
 stomach   moderately
Reproductivefemale systembreastmammary gland moderately
 female systemplacenta  moderately
 female systemuterus  highly
 male systemtestis  highly
Urinarybladder   predominantly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
Nervousperipherous   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated PhosphoP
mono polymer complex
HOMOLOGY
interspecies ortholog to murine Tebp
Homologene
FAMILY p23/wos2 family
CATEGORY chaperone/stress
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
intracellular,nucleus,chromatin/chromosome,telomere
text telomerase holoenzyme complex
basic FUNCTION
  • localizing to genomic response elements in a hormone-dependent manner
  • disrupting receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes
  • plays an important role in estrogen receptor alpha (ER) signal transduction
  • differentially regulates ER target genes and is involved in the control of distinct cellular processes in breast tumor development, thus revealing novel functions of this cochaperone
  • modulates Hsp90 activity during the final stages of the chaperone pathway to facilitate maturation of client proteins
  • inhibiting HSP90AA1
  • PTGES3 and KAT2A were required to maintain open chromatin regions along the genome indicating that dynamic protein behavior is a critical feature of various DNA-associated events
  • initiates the disassembly process by accelerating the off-rate of protein-DNA complexes
  • PTGES3 molecular chaperone and KAT2A acetyltransferase cooperate to modulate the stabilities of a wide range of protein-DNA complexes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • telomerase holoenzyme complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • telomerase
  • progesterone receptor
  • PTGES3 regulates both KAT2A acetylase and HSF1 DNA binding activities
  • because methylation represses ESR1 activity, the observed complex formation between SMYD2 and HSP90AA1/PTGES3 may contribute to ESR1 regulation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    may promote tumor progression and poor prognosis by increasing metastatic potential and drug resistance in breast cancer patients
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • cPGES/p23(-/-) pups die during the perinatal period and display retarded lung development reminiscent of the phenotype of GR-deficient neonates