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FLASH GENE
Symbol PTGES2 contributors: SGE/npt/pgu - updated : 27/04/2010
HGNC name prostaglandin E synthase 2
HGNC id 17822
Location 9q34.11      Physical location : 130.882.972 - 130.890.712
Synonym name
  • chromosome 9 open reading frame 15
  • microsomal prostaglandin E synthase 2
  • GATE-binding factor 1
  • gamma-interferon-activated transcriptional element-binding factor 1
  • membrane-associated prostaglandin E synthase 2
    • Synonym symbol(s) C9orf15, FLJ14038, GBF1, PGES2, MGC11289, mPGES-2
    EC.number 5.3.99.3
    DNA
    TYPE functioning gene
    SPECIAL FEATURE head to head
    STRUCTURE 7.74 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC138428 9q34.13 hypothetical protein LOC138428 TTC16 9q34.13 tetratricopeptide repeat domain 16 TOR2A 9q34.11 torsin family 2, member A SH2D3C 9q34.13 SH2 domain containing 3C CDK9 9q34.1 cyclin-dependent kinase 9 (CDC2-related kinase) FPGS 9cen-q34.11 folylpolyglutamate synthase ENG 9q34.1 endoglin (Osler-Rendu-Weber syndrome 1) AK1 9q34.12 adenylate kinase 1 ST6GALNAC6 9q34.13 adenylate kinase 1 SIAT7D 9q34.1 sialyltransferase 7D ((alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialyltransferase) MGC46424 9q34.13 hypothetical protein MGC46424 LOC389790 9 similar to phosphatidylinositol phosphate kinase-like protein DPM2 9q34.13 dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit FLJ10232 9q34.13 hypothetical protein FLJ10232 DKFZp762G199 9q34.13 hypothetical protein DKFZp762G199 MCSC 9q34.13 mitochondrial Ca2+-dependent solute carrier PTGES2 9q34.13 prostaglandin E synthase 2 LOC389791 9 hypothetical gene supported by AK094537 LCN2 9q34 lipocalin 2 (oncogene 24p3) C9orf16 9q34.1 chromosome 9 open reading frame 16 CIZ1 9q34.13 chromosome 9 open reading frame 16 DNM1 9q34 dynamin 1 GOLGA2 9q34.13 golgi autoantigen, golgin subfamily a, 2 LOC375757 9q34.13 hypothetical protein LOC375757 FLJ21673 9q34.13 hypothetical protein FLJ21673 CLONE24922 COQ4 9q34.13 coenzyme Q4 homolog (yeast) TMSL4 9 thymosin-like 4 SLC27A4 9q34.13 solute carrier family 27 (fatty acid transporter), member 4 C9orf74 9q34.13 chromosome 9 open reading frame 74 CEECAM1 9q34.13 cerebral endothelial cell adhesion molecule 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 2120 42 377 - 2002 11866447
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheartventricle   
     heartatrium   
    Digestivestomach   highly
    Endocrinepancreas   highly
    Lymphoid/Immunelymph node    
     tonsils   highly
    Nervousbrain    
    Reproductivefemale systemuteruscervix highly
    Respiratoryrespiratory tracttrachea   
    Urinarykidney    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo, fetal
    Text fetal heart
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one glutaredoxin domain
  • one GST C-terminal domain
    • mono polymer homomer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • GST superfamily
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • catalyzing the conversion of prostaglandin H2 to prostaglandin E2 involved in both tissue homeostasis and disease
  • activating the transcription regulated by a gamma-interferon-activated transcription element (GATE)
  • PTGES and PTGES2 may each play a role in colorectal cancer progression
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    prostaglandin biosynthesis
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
  • dihydrolipoic acid
    • protein
  • may interact with CEBP
  • interacting with EXOSC10
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in colorectal cancer
    tumoral     --over  
    overexpressed in glioma, in both low- and high-grade tumors
    Susceptibility to type 2 diabetes
    Variant & Polymorphism SNP
  • R298H polymorphism was significantly associated with impaired glucose tolerance and type 2 diabetes
  • a marginal but significant influence of PTGES2 R298H SNP on body mass index
    • Candidate gene
  • may play a role in colorectal cancer progression
    • Marker
    Therapy target
    ANIMAL & CELL MODELS