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FLASH GENE
Symbol PTGER4 contributors: - updated : 11-06-2011
HGNC name prostaglandin E receptor 4 (subtype EP4)
HGNC id 9596
Location 5p13.1      Physical location : 40.680.031 - 40.693.835
Synonym name
  • PGE receptor, EP4 subtype
  • prostaglandin E receptor 4, subtype EP4
    • Synonym symbol(s) EP4, EP4R
    DNA
    TYPE functioning gene
    STRUCTURE 13.00 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 3432 - - - 1995 7759114
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Hearing/Equilibriumear     Homo sapiens
    Lymphoid/Immunelymph node   highly
    Nervousnervecranial nerve  lowly
    Respiratoryrespiratory tracttrachea  moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    Connectiveadipose  highly
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    Blood/Hematopoieticplatelet Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    		a seven transmembrane segments receptor (7tm_1)
    HOMOLOGY
    interspecies homolog to rattus Ptger4 (88.87 pc)
    homolog to murine Ptger4 (88.87 pc)
    Homologene
    FAMILY G-protein coupled receptor 1 superfamily
    CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses
  • involved in the regulation of collagen type-1, MMP1 & MMP3 in human tendon fibroblasts
  • transducing Prostaglandin E2 (PGE2) signal
  • mediating IL-1beta metabolism via the p38 MAPK pathway in human tendon fibroblasts
  • may play a major role in the tendon's degenerative changes
  • directly involved in regulation of proliferation and invasion of inflammatory breast cancer cells
  • involved in mechanisms for prostaglandin E(1) actions on the cochlea
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS ossification
    PATHWAY
    metabolism
    signaling signal transduction
    p38 MAPK pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to Crohn disease
    Variant & Polymorphism other
  • increasing the risk of Crohn disease
    • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    bloodcoagulation 
    EP4 receptor activation is a novel antithrombotic strategy
    neurosensorialear 
    local PTGER4 agonist treatment could attenuate acute sensorineural hearing loss
    ANIMAL & CELL MODELS