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FLASH GENE
Symbol PTGER2 contributors: mct/npt - updated : 22-03-2010
HGNC name prostaglandin E receptor 2 (subtype EP2), 53kDa
HGNC id 9594
Location 14q22.1      Physical location : 52.781.015 - 52.795.320
Synonym name
  • prostaglandin E2 receptor EP2 subtype
  • prostanoid EP2 receptor
  • Synonym symbol(s) EP2
    DNA
    TYPE functioning gene
    STRUCTURE 14.31 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - D14S70 - D14S253 - TTF1 - D14S1053 - D14S984 - PYGL - D14S978 - PTGER2 - D14S989 - D14S281 - qter
    Authors GeneMap
    Physical map
    SPG3A 14q21.3 spastic paraplegia 3A (autosomal dominant) SNRPGP 14 small nuclear ribonucleoprotein polypeptide G pseudogene SAV1 14q13-q23 salvador homolog 1 (Drosophila) ZNF405P 14 zinc finger protein 405 pseudogene NIN 14q21.3-q22 ninein (GSK3B interacting protein) C14orf29 14q21.3 chromosome 14 open reading frame 29 PYGL 14q21.2 phosphorylase, glycogen; liver (Hers disease, glycogen storage disease type VI) MRP63P9 14q22.1 mitochondrial ribosomal protein 63 pseudogene 9 TRIM9 14q21.3 tripartite motif-containing 9 TXNDC 14q21.3 thioredoxin domain containing LOC283553 14q22.1 hypothetical LOC283553 SETP2 14 SET pseudogene 2 C14orf31 14q21.3 chromosome 14 open reading frame 31 LOC341856 14q22.1 similar to putative taste receptor HTR2 C14orf166 14q22.1 chromosome 14 open reading frame 166 NID2 14q21-q22 nidogen 2 (osteonidogen) COX5AP2 14 cytochrome c oxidase subunit Va pseudogene 2 PTGDR 14q22.1 prostaglandin D2 receptor (DP) PTGER2 14q21.2 prostaglandin E receptor 2 (subtype EP2), 53kDa KIAA1344 14q22.1 KIAA1344 DKFZp762F0713 14q22.1 hypothetical protein DKFZp762F0713 ERO1L 14q22.1 ERO1-like (S. cerevisiae) PSMC6 12q15 proteasome (prosome, macropain) 26S subunit, ATPase, 6 STYX  serine/threonine/tyrosine interacting protein GNPNAT1 14q22.1 glucosamine-phosphate N-acetyltransferase 1 PLEKHC1 14q22.1 pleckstrin homology domain containing, family C (with FERM domain) member 1 NDUFB3P3 14q22.3-q23.1 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa pseudogene 3 DDHD1 14q21 DDHD domain containing 1 BMP4 14q22-q23 bone morphogenetic protein 4 LOC341862 14q22.1 similar to ATP synthase gamma chain, mitochondrial precursor
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 2494 - 358 - Smock (1999)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Lymphoid/Immunespleen    
     thymus    
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    Connectivecartilage  highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • seven transmembrane segments (7TM) receptor
  • HOMOLOGY
    Homologene
    FAMILY
  • G-protein coupled receptor 1 family
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • PGE2/ PTGER2 complex may regulate neoplastic cell function in cervical carcinoma in an autocrine/paracrine manner
  • promotes the growth of articular chondrocytes
  • PTGER2 receptor-cAMP signalling pathway implicated in the stimulation of progesterone production and 11betaHSD1 activity by prostaglandin E(2) in granulosa-lutein cells (Chandras 2007)
  • directs prostaglandin E2-mediated fibroblast responses via regulation of PTGER2 expression (Sagana 2009)
  • potential roles of inflammatory reaction by PTGER2 upregulation in carcinogenic process to microsatellite instability-high colorectal cancer (Baba 2010)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other regulatrd by PTEN (PTEN directly regulates Prostaglandin E(2) inhibition of fibroblast activation by augmenting PTGER2 expression) (Sagana 2009)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    by epigenetic silencing is associated with progression of neuroblastomas (Sugino 2007)
    tumoral     --over  
    associated with worse prognosis, and correlated positively with tumor invasion status in esophageal squamous cell carcinoma (Kuo 2009)
    tumoral     --low  
    by aberrant methylation of the PTGER2 gene observed frequently in nonsmall cell lung cancer tissues and associated with the presence of EGFR mutation and a better prognosis (Tian 2008)
    Susceptibility to aspirin-intolerant asthma (AIA)
    Variant & Polymorphism SNP SNP associated with the susceptibility to AIA
    Candidate gene
    Marker
    Therapy target PTGER2 agonist is a candidate for a new therapeutic compound for the treatment of degenerative cartilage diseases
    ANIMAL & CELL MODELS