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FLASH GENE
Symbol PTGER1 contributors: - updated : 02-01-2006
HGNC name prostaglandin E receptor 1 (subtype EP1), 42kDa
HGNC id 9593
Location 19p13.1      Physical location : 14.583.278 - 14.586.174
Synonym symbol(s) EP1
DNA
TYPE functioning gene
STRUCTURE 2.00 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunespleen   highly
Respiratorylung   moderately
Urinarykidney   highly
Visualeyeuvea   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connective    
Epithelial    
Muscularstriatum   
cells
SystemCellPubmedSpeciesStageRna symbol
Visualcone photoreceptor
Visualganglion cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
seven transmembrane segments (7TM) receptor
HOMOLOGY
Homologene
FAMILY G protein coupled receptor superfamily
CATEGORY signaling , receptor
SUBCELLULAR LOCALIZATION     plasma membrane
basic FUNCTION
  • may play a role as an important modulator of renal function
  • implicated in the smooth muscle contractile in response to prostaglandin in various tissues
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene for behavioral traits in del 19p13.12
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    Ptger1-null mice show behavioral inhibition and impulsive aggression with defective social interaction