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FLASH GENE
Symbol PTGDR2 contributors: mct - updated : 18-06-2011
HGNC name G protein-coupled receptor 44
HGNC id 4502
Location 11q12.2      Physical location : -
Synonym name chemoattractant receptor-homologous molecule expressed on TH2 cells
Synonym symbol(s) CRTH2, CD294, GPR44
DNA
TYPE anonymous DNA segment
STRUCTURE 5.05 kb     2 Exon(s)
regulatory sequence Promoter
Binding site
text structure
  • promoter contains a number of potential GATA, NFAT, STAT binding motifs
  • GATA-3 binding to a probe from the GPR44 promoter
  • MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 2910 - 395 - 2007 17878378
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticthymus    
    Cardiovascularheart    
    Endocrinepancreas    
    Nervousbrainforebraincerebral cortexfrontal  Homo sapiens
     brainhindbrainpons   Homo sapiens
     braindiencephalonhypothalamus   Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticbasophil
    Blood/Hematopoieticeosinophil
    Blood/Hematopoieticleukocyte Homo sapiens
    Lymphoid/ImmuneT cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text liver
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • 7 putative transmembrane domains (TMs)
  • specific AAs in the C-tail implicated in the agonist-induced internalization and the recycling of the receptor
  • HOMOLOGY
    intraspecies homolog to chemoattractant receptor
    Homologene
    FAMILY G protein coupled receptor family
    CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • not retained in the ER in the presence of ANKRD13C and also showed that ANKRD13C did not co-localize with GPR44 at the plasma membrane
  • basic FUNCTION
  • mediator in the regulation of inflammatory responses
  • mediating signals to the interior of the cell via activation of heterotrimeric G proteins that in turn activate various effector proteins, ultimately resulting in a physiologic response
  • mediating the chemotaxis of eosinophils, basophils, and Th2 lymphocytes
  • PTGDR and PTGDR2, act in concert to promote a number of biological effects associated with the development and maintenance of the allergic response
  • PTGDS and its receptor chemoattractant receptor homologous molecule expressed on T(h)2 cells (GPR44) have been implicated in the pathogenesis of numerous allergic diseases
  • has a pivotal role in mediating the inflammation and the underlying immune response following epicutaneous sensitization
  • novel function in mediating an inhibitory effect of PTGDS on the apoptosis of human Th2 cells induced by cytokine deprivation
  • could modulate the neuroimmunoregulatory axis in allergic eosinophil inflammation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • receptor of prostaglandin D2 (PGD2), mediating the pro-inflammatory effects of prostaglandin D(2) (PGD(2)) generated in allergic inflammation
  • interaction between ANKRD13C and GPR44
  • strong association between VIP and PTGDR2 in eosinophil chemotaxis
  • specific chemotaxis signal for VIP in eosinophil that is mediated through the PTGDR2 and involves the PKA and PKC pathways
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism SNP 1651G associated with higher degree of bronchial hyperresponsiveness and asthma
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS