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FLASH GENE
Symbol PTDSS2 contributors: KTN/npt - updated : 30/10/2008
HGNC name phosphatidylserine synthase 2
HGNC id 15463
Location 11p15      Physical location : 450.279 - 491.386
Synonym name
  • PtdSer synthase 2
  • serine-exchange enzyme II
  • Synonym symbol(s) PSS2
    EC.number 2.7.8.-
    DNA
    TYPE functioning gene
    STRUCTURE 41.11 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC390028 11 similar to Olfactory receptor 4F3 LOC387731 11 similar to bA476I15.3 (novel protein similar to septin) LOC387732 11 LOC387732 RYD5 11p15.5 ligand binding protein RYD5 ODF3 11p15.5 outer dense fiber of sperm tails 3 BET1L 11p15.5 blocked early in transport 1 homolog (S. cerevisiae) like RIC-8 11p15.5 likely ortholog of mouse synembryn SIRT3 11p15.5 sirtuin (silent mating type information regulation 2 homolog) 3 (S. cerevisiae) PSMD13 11p15.5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 NALP6 11p15 NACHT, leucine rich repeat and PYD containing 6 FLJ22635 11p15.5 hypothetical protein FLJ22635 LOC387733 11 similar to putative haemopoietic membrane protein MRPS24P1 11p15.4 mitochondrial ribosomal protein S24 pseudogene IFITM2 11p15.5 interferon induced transmembrane protein 2 (1-8D) IFITM1 11p15.5 interferon induced transmembrane protein 1 (9-27) IFITM3 11p15.5 interferon induced transmembrane protein 3 (1-8U) PKP3 11p15 plakophilin 3 LOC387734 11 similar to beta 1,4-N-acetylgalactosaminyltransferase-transferase-III FLJ25045 11p15.5 hypothetical protein FLJ25045 SIGIRR 11p15.5 single Ig IL-1R-related molecule PTDSS2 11p15 phosphatidylserine synthase 2 RNH 11p15.5 ribonuclease/angiogenin inhibitor LOC387735 11 similar to Collagen alpha 1(V) chain precursor HRAS 11p15.5 v-Ha-ras Harvey rat sarcoma viral oncogene homolog DKFZp761L1518 11p15.5 hypothetical protein DKFZp761L1518 MGC35138 11p15.5 hypothetical protein MGC35138 C11orf13 11p15,5 chromosome 11 open reading frame 13 KIAA1542 11p15.5 CTD-binding SR-like protein rA9 IRF7 11p15,5 interferon regulatory factor 7 MUCDHL 11p15,5 mucin and cadherin-like SCT 11p15.5 secretin DRD4 11p15.5 dopamine receptor D4 LOC387736 11 LOC387736 DEAF1 11p15,5 deformed epidermal autoregulatory factor 1 (Drosophila) LOC283232 11p15.5 hypothetical protein LOC283232 EPS8L2 11p15.5 EPS8-like 2 TALDO1 11p15.5-p15.4 transaldolase 1 FLJ34283 11p15.5 hypothetical protein FLJ34283 NS3BP 11p15.5 NS3BP BM88 11p15.5 NS3BP SLC25A22 11p15.5 solute carrier family 25 (mitochondrial carrier: glutamate), member 22 LOC387737 11 LOC387737 LRDD 11pter-p15.5 leucine-rich and death domain containing
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 2473 56.1 487 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestine   moderately
     pancreas exocrine   highly
     salivary gland   predominantly
    Endocrineparathyroid   moderately
    Nervousnerve   highly
    Reproductivemale systemtestis  moderately
    Visualeye   highly
    cell lineage
    cell lines
    fluid/secretion highly in blood and lymph
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated GlycoP
    HOMOLOGY
    interspecies homolog to dog PTDSS2 (90.7 pc)
    homolog to chimpanzee PTDSS2 (97.5 pc)
    homolog to rattus Ptdss2 (91.7 pc)
    homolog to murine Ptdss2 (92.1 pc)
    homolog to chicken PTDSS2 (87.5 pc)
    Homologene
    FAMILY
  • phosphatidyl serine synthase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text
  • mitochondria-associated membrane
  • multi-pass membrane protein
  • basic FUNCTION
  • catalyzing a base-exchange reaction in which the polar head group of phosphatidylethanolamine is replaced by L-serine
  • acting as a CDP-diacylglycerol-serine O-phosphatidyltransferase
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism other
    signaling
  • phospholipid metabolism
  • phosphatidylserine biosynthesis
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    inhibited by excess phosphatidylserine
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS