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FLASH GENE
Symbol PTDSS1 contributors: KTN/npt - updated : 23/10/2008
HGNC name phosphatidylserine synthase 1
HGNC id 9587
Location 8q22      Physical location : 97.274.166 - 97.346.774
Synonym name
  • serine exchange enzyme 1
  • PtdSer synthase 1
  • Synonym symbol(s) PSS1, PSSA, KIAA0024
    EC.number 2.7.8.-
    DNA
    TYPE functioning gene
    STRUCTURE 72.61 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    GEM 8q22.3 GTP binding protein overexpressed in skeletal muscle LOC392252 8 similar to ribosomal protein S4, X-linked RAD54B 8q21.3-q22 similar to ribosomal protein S4, X-linked FSBP 8q22.1 fibrinogen silencer binding protein DKFZP434I116 8q22.1 DKFZP434I116 protein FLJ20171 8q22.1 hypothetical protein FLJ20171 LOC286148 8q22.1 hypothetical protein LOC286148 FLJ20530 8q22.1 hypothetical protein FLJ20530 CCNE2 8q22.1 cyclin E2 LOC392253 8 similar to Ac2-210 TP53INP1 8q22 tumor protein p53 inducible nuclear protein 1 MGC40214 8q22.1 hypothetical protein MGC40214 PLEKHF2 8q22.1 pleckstrin homology domain containing, family F (with FYVE domain) member 2 LOC157657 8q22.1 hypothetical protein LOC157657 LOC392254 8 similar to glyceraldehyde-3-phosphate dehydrogenase LOC392255 8 similar to growth and differentiation factor 6 UQCRB 8q22 ubiquinol-cytochrome c reductase binding protein CGI-12 8q22.1 CGI-12 protein PTDSS1 8q22 phosphatidylserine synthase 1 SDC2 8q22-q23 syndecan 2 (heparan sulfate proteoglycan 1, cell surface-associated, fibroglycan) PGCP 8q22.2 plasma glutamate carboxypeptidase KIAA1750 8q22.1 KIAA1750 protein LOC286150 8q22.1 similar to 40S ribosomal protein S2 LYRIC 8q22.1 LYRIC/3D3 LAPTM4B 8q22.1 lysosomal associated protein transmembrane 4 beta LOC389678 8 similar to hypothetical protein LOC51249 RPS23P1 8q23 ribosomal protein S23 pseudogene 1 MATN2 8q22 matrilin 2 RPL30 8q22-q24 ribosomal protein L30 FLJ39553 8q22.2 hypothetical protein FLJ39553 UK114 8q22 hypothetical protein FLJ39553 POP1 8q22.1 processing of precursors 1 FLJ13955 8q22.2 hypothetical protein FLJ13955
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 2504 55.4 473 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineplacenta   moderately
    Lymphoid/Immunetonsils   moderately
    Respiratorylung   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  moderately
    Connectivebone  moderately
    Muscular   moderately
    cell lineage
    cell lines
    fluid/secretion moderately in blood, predominantly in lymph
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • putative membrane-spanning domain
  • HOMOLOGY
    interspecies homolog to dog PTDSS1 (96.2 pc)
    homolog to chimpanzee PTDSS1 (100 pc)
    homolog to cow PTDSS1 (97.7 pc)
    homolog to rattus Ptdss1 (97 pc)
    homolog to murine Ptdss1 (97.3 pc)
    Homologene
    FAMILY
  • phosphatidyl serine synthase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    text multi-pass membrane protein
    basic FUNCTION
  • catalyzing a base-exchange reaction in which the polar head group of phosphatidylcholine is replaced by L-serine
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
  • phosphatidylserine biosynthesis
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS