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FLASH GENE
Symbol PTDSS1 contributors: KTN/npt - updated : 23/10/2008
HGNC name phosphatidylserine synthase 1
HGNC id 9587
Location 8q22      Physical location : 97.274.166 - 97.346.774
Synonym name
  • serine exchange enzyme 1
  • PtdSer synthase 1
  • Synonym symbol(s) PSS1, PSSA, KIAA0024
    EC.number 2.7.8.-
    DNA
    TYPE functioning gene
    STRUCTURE 72.61 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 2504 55.4 473 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineplacenta   moderately
    Lymphoid/Immunetonsils   moderately
    Respiratorylung   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  moderately
    Connectivebone  moderately
    Muscular   moderately
    cell lineage
    cell lines
    fluid/secretion moderately in blood, predominantly in lymph
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • putative membrane-spanning domain
  • HOMOLOGY
    interspecies homolog to dog PTDSS1 (96.2 pc)
    homolog to chimpanzee PTDSS1 (100 pc)
    homolog to cow PTDSS1 (97.7 pc)
    homolog to rattus Ptdss1 (97 pc)
    homolog to murine Ptdss1 (97.3 pc)
    Homologene
    FAMILY
  • phosphatidyl serine synthase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    text multi-pass membrane protein
    basic FUNCTION
  • catalyzing a base-exchange reaction in which the polar head group of phosphatidylcholine is replaced by L-serine
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
  • phosphatidylserine biosynthesis
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS