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FLASH GENE
Symbol PTAFR contributors: mct - updated : 10-03-2017
HGNC name platelet-activating factor receptor
HGNC id 9582
Location 1p35.3      Physical location : 28.473.677 - 28.520.447
Synonym symbol(s) PAFR
DNA
TYPE functioning gene
STRUCTURE 46.77 kb     2 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
Physical map
LOC391022 1 similar to DC2 protein LOC388610 1 LOC388610 MGC16491 1p35.3 hypothetical protein MGC16491 SLC9A1 1p35 solute carrier family 9 (sodium/hydrogen exchanger), isoform 1 (antiporter, Na+/H+, amiloride sensitive) LOC391023 1 similar to ribosomal protein L18a; 60S ribosomal protein L18a LOC284609 1p35.3 similar to hypothetical protein FLJ20420 LOC148356 1p35.3 similar to nucleophosmin 1; nucleolar phosphoprotein B23; numatrin; nucleophosmin/nucleoplasmin family, member 1 WDTC1 1p35.3 WD and tetratricopeptide repeats 1 DKFZP564D0478 1p35.3 hypothetical protein DKFZp564D0478 JFC1 1p35.3 hypothetical protein DKFZp564D0478 MAP3K6 1p35.2 mitogen-activated protein kinase kinase kinase 6 FCN3 1p36-p32 ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen) LOC388611 1 similar to EAPG6122 GPR3 1p35.1-p34.3 G protein-coupled receptor 3 WASF2 1p36.11-p34.3 WAS protein family, member 2 DJ159A19.3 1p36.13 hypothetical protein DJ159A19.3 LOC388612 1 LOC388612 FGR 1p35 Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog G1P3 1p35 interferon, alpha-inducible protein (clone IFI-6-16) LOC339409 1p35.3 similar to Procollagen (type III) N-endopeptidase MGC34648 1p35.3 hypothetical protein MGC34648 STX12 1p35-p34.1 syntaxin 12 PPP1R8 1p35 protein phosphatase 1, regulatory (inhibitor) subunit 8 C1orf38 1p35.2 chromosome 1 open reading frame 38 RPA2 1p35 replication protein A2, 32kDa ASML3B 1p35.2 acid sphingomyelinase-like phosphodiesterase FLJ10307 1p35.2 hypothetical protein FLJ10307 EYA3 1p36 eyes absent homolog 3 (Drosophila) LOC388613 1 similar to Microsomal signal peptidase 25 kDa subunit (SPase 25 kDa subunit) (SPC25) LOC391024 1 similar to RIKEN cDNA 2610313E07 PTAFR 1p35.1-p34.3 platelet-activating factor receptor DNAJC8 1p35.3 DnaJ (Hsp40) homolog, subfamily C, member 8 ATPIF1 1p35.3 ATPase inhibitory factor 1 SESN2 1p35.3 sestrin 2 FLJ20045 1p35.2 TRAP/mediator complex subunit p28b FLJ13171 1p35 TRAP/mediator complex subunit p28b CHC1 1p36.1 chromosome condensation 1 SECP43 1p35.2 tRNA selenocysteine associated protein LOC85028 1p35.2 PNAS-123 MGC45806 1p35.2 hypothetical protein MGC45806 TAF12 1p35.2 TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa GMEB1 1p35.2 glucocorticoid modulatory element binding protein 1 HGRG8 14q12-q21 high-glucose-regulated protein 8 OPRD1 1p36.1-p34.3 opioid receptor, delta 1 EPB41 1p36.1-p35 erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 4109 - 342 - 2014 25182608
3 - 4191 - 342 - 2014 25182608
2 - 4247 - 342 - 2014 25182608
3 - 4318 - 342 - 2014 25182608
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymph node    
Urinarykidneytubule  highly Homo sapiens
Visualeye    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticneutrophil Homo sapiens
cell lineage
cell lines
fluid/secretion blood
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
  • seven transmembrane segments (7TM) receptor
  • conserved proline in TM6 is crucial for intracellular trafficking of PTAFR
  • seven hydrophobic regions interspersed with polar peptide segments, characteristic of rhodopsin-type G protein-dependent receptors
  • HOMOLOGY
    Homologene
    FAMILY receptor,G protein coupled receptor superfamily
    CATEGORY signaling cytokine , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus
    text
  • presence of PAF receptor (PTAFR) at intracellular sites such as the nucleus
  • basic FUNCTION
  • platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth- muscle contractile and hypotensive activity
  • early Endothelial progenitor cell (EPC) express the PTAFR and respond to PAF signaling via a transient increase of cytoplasmic Ca(2+) concentration
  • is involved in the clearance of apoptotic cells by macrophages, and that this is associated with anti-inflammatory phenotype
  • PAFR signaling contributes to a pro-inflammatory environment in the model of obstructive nephropathy, favoring the fibrotic process, which lately will generate renal dysfunction and progressive organ failure
  • in the absence of PTAFR signalling, monocytes and macrophages acquire a pro-inflammatory phenotype, resulting in adipose tissue inflammation and metabolic dysfunction
  • nuclear PTAFR is responsible for the upregulation of unique set of growth factors, including vascular endothelial growth factor
  • nuclear PTAFR translocates in an agonist-independent manner, and distinctive functions of PTAFR based on its cellular localization point to another dimension needed for pharmacologic selectivity of drugs
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
  • recognition of apoptotic cells by phagocytes leads to activation of PTAFR pathways, resulting in a microenvironment response favorable to melanoma growth
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • phagocytosis of apoptotic cells engages CD36 and PTAFR, possibly in lipid rafts, and this is required for optimal efferocytosis and the establishment of the macrophage regulatory phenotype
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • a lower expression of PTAFR correlated with poor differentiation and a poor prognosis, and may be used as a prognostic marker in hepatocellular carcinoma after hepatectomy
  • Therapy target
    SystemTypeDisorderPubmed
    cardiovascular  
    PTAFR antagonists, administered in combination with chemotherapy, may represent a promising strategy for cancer treatment
    ANIMAL & CELL MODELS
  • Pafr(-/-) mice fed with high-refined carbohydrate-containing (HC) diet showed more steatosis, oxidative stress and higher transaminases levels associated with lower inflammation than WT mice