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FLASH GENE
Symbol PSTPIP2 contributors: KTN - updated : 26-03-2008
HGNC name proline-serine-threonine phosphatase interacting protein 2
HGNC id 9581
Location 18q12      Physical location : 43.563.502 - 43.652.250
Synonym symbol(s) MAYP, MGC34175
DNA
TYPE functioning gene
STRUCTURE 88.00 kb     14 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Physical map
LOC342732 18q21.1 similar to cytokeratin 8 LOC388475 18 LOC388475 SETBP1 18q21.1 SET binding protein 1 SLC14A2 18q12.1-q21.1 solute carrier family 14 (urea transporter), member 2 SLC14A1 18q12 solute carrier family 14 (urea transporter), member 1 (Kidd blood group) LOC284266 KIAA1632 18q21.1 KIAA1632 protein PSTPIP2 18q12 proline-serine-threonine phosphatase interacting protein 2 ATP5A1 18q12-q21 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit, isoform 1, cardiac muscle LOC115106 MGC12909 18q21.1 hypothetical protein MGC12909 FLJ34218 18q21.1 hypothetical protein FLJ34218 FLJ32670 18q21.1 hypothetical protein FLJ32670 SIAT8E 18q12.3-q21.1 sialyltransferase 8E (alpha-2, 8-polysialyltransferase) MIZ1 18q12.1-q12.3 sialyltransferase 8E (alpha-2, 8-polysialyltransferase) TCEB3L2 18q12,3 sialyltransferase 8E (alpha-2, 8-polysialyltransferase) TCEB3L 18q21.1 sialyltransferase 8E (alpha-2, 8-polysialyltransferase) DKFZP564D1378 18q21.1 hypothetical protein DKFZp564D1378 HSPC039 18q12 HSPC039 protein LOC390851 18 similar to RIKEN cDNA C230094B15 LOC201411 18q21.1 similar to Thiopurine S-methyltransferase (Thiopurine methyltransferase) MADH2 18q21 MAD, mothers against decapentaplegic homolog 2 (Drosophila)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
14 - 3054 38 334 - -
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunespleen   highly
Reproductivemale systemtestis   
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immunemacrophage
cell lineage
cell lines macrophage cell lines BAC1.2F5 and J774.2
fluid/secretion moderately in blood
at STAGE
physiological period fetal
Text predominantly in umbilical cord
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a Fes/CIP4 homology domain
  • a coiled-coil domain
  • two potential SH3 binding sites
  • a proline-rich region
  • conjugated PhosphoP
    mono polymer homomer , oligo
    HOMOLOGY
    interspecies homolog to dog PSTPIP2 (88.9 pc)
    homolog to chimpanzee PSTPIP2 (99.2 pc)
    homolog to murine Pstpip2 (89.9 pc)
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    text
  • peripheral membrane protein
  • basic FUNCTION
  • may be implicated in cytoskeletal regulation via the CSF-1-induced reorganization of the actin cytoskeleton
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • phosphorylated on tyrosine
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds a PEST-type protein tyrosine phosphatase
  • associates directly or indirectly with actin
  • cell & other
    REGULATION
    Other phosphorylated on tyrosine
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS