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FLASH GENE
Symbol PSPN contributors: mct - updated : 06-01-2007
HGNC name persephin
HGNC id 9579
Location 19p13.3      Physical location : 6.375.305 - 6.375.860
Synonym symbol(s) PSP
DNA
TYPE functioning gene
STRUCTURE 0.00 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systemovary  highly
Respiratorylung    
cell lineage
cell lines
fluid/secretion secreted
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , dimer
HOMOLOGY
intraspecies homolog to GDNF
homolog to neurturin
Homologene
FAMILY
  • TGFB family, GDNF subfamily
    • CATEGORY signaling growth factor , transport
    SUBCELLULAR LOCALIZATION extracellular
    text secreted
    basic FUNCTION
  • promoting the survival of ventral midbrain dopaminergic neurons in culture and prevents their degeneration after treatment by 6 hydroxydopamine in vivo
  • exhibiting neurotrophic activity on mesencephalic dopaminergic and motor neurons
  • involved in processes subserving both the organization of the cortical region during development and the functional activity and maintenance of the mature hippocampal neurons
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text neurogenesis (central nervous system)
    PATHWAY
    metabolism
    signaling
    a component homodimer, disulfide-linked
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS