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FLASH GENE
Symbol PSPH contributors: mct/npt - updated : 29-03-2008
HGNC name phosphoserine phosphatase
HGNC id 9577
Corresponding disease
PSPHD phosphoserine phosphatase deficiency
Location 7p11.2      Physical location : 56.078.745 - 56.119.268
Synonym name
  • O-phosphoserine phosphohydrolase
  • L-3-phosphoserine phosphatase
  • Synonym symbol(s) PSP, SERB, PSPase
    EC.number 3.1.3.3
    DNA
    TYPE functioning gene
    STRUCTURE 40.52 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    LOC392908 7 similar to KIAA0565 protein FKBP9L 7p11.1 FK506 binding protein 9-like DKFZP564K0822 7p11.2 hypothetical protein DKFZp564K0822 LOC392674 7 similar to SMT3 suppressor of mif two 3 homolog 2 LOC392675 7 similar to hypothetical protein LOC349114 LOC392909 7 similar to septin 10 isoform 1 LOC392032 7 similar to cell division cycle 42 isoform 2; cell division cycle 42 (GTP-binding protein, 25kD); GTP-binding protein, 25kD; cell division cycle 42 (GTP binding protein, 25kD) LOC392033 7 similar to tubulin, beta 5 FLJ39963 7p11.2 hypothetical protein FLJ39963 LOC392034 7 similar to KIAA0565 protein FKBP9L 7p11.1 FK506 binding protein 9-like MRPS17 7p11-q11.21 mitochondrial ribosomal protein S17 GBAS 7p12 glioblastoma amplified sequence LOC389491 7 similar to SMT3 suppressor of mif two 3 homolog 2 LOC389492 7 similar to hypothetical protein LOC349114 PSPH 7p15 phosphoserine phosphatase CCT6A 7q32-q33 chaperonin containing TCP1, subunit 6A (zeta 1) LOC346288 7p11.2 similar to septin 10 isoform 1 SUMF2 7q11.1 sulfatase modifying factor 2 PHKG1 7p12-q21 phosphorylase kinase, gamma 1 (muscle) C7orf17 7p11.2 chromosome 7 open reading frame 17 LOC392676 7 similar to Protein p8 (Candidate of metastasis 1) LOC392910 7 similar to Interferon-induced transmembrane protein 3 (Interferon-inducible protein 1-8U) FLJ39963 7p11.2 hypothetical protein FLJ39963 LOC392677 7 hypothetical gene supported by NM_007235 MRPS17 7p11-q11.21 mitochondrial ribosomal protein S17 GBAS 7p12 glioblastoma amplified sequence PSPH 7p15 phosphoserine phosphatase CCT6A 7q32-q33 chaperonin containing TCP1, subunit 6A (zeta 1) SUMF2 7q11.1 sulfatase modifying factor 2 PHKG1 7p12-q21 phosphorylase kinase, gamma 1 (muscle) C7orf17 7p11.2 chromosome 7 open reading frame 17 LOC392678 7 similar to hypothetical protein LOC349114 LOC389493 7 similar to Protein p8 (Candidate of metastasis 1) LOC392035 7 similar to Interferon-induced transmembrane protein 3 (Interferon-inducible protein 1-8U) LOC392679 7 similar to KIAA1074 protein LOC340232 7p11.2 similar to Exportin T (tRNA exportin) (Exportin(tRNA)) LOC392911 7 similar to zinc finger protein 43 (HTF6) DKFZp434L192 7p11.2 hypothetical protein DKFZp434L192 LOC392912 7 similar to hypothetical protein 9630041N07 LOC392680 7 LOC392680 LOC154937 7p11.2 protein phosphatase 2, regulatory subunit B (B56), epsilon isoform pseudogene LOC392913 7 hypothetical gene supported by AF117108 LOC389494 7 similar to hypothetical protein LOC349114 LOC392914 7 similar to zinc finger protein 43 (HTF6) LOC254027 7p11.2 similar to KIAA1074 protein LOC392915 7 similar to zinc finger protein 43 (HTF6) LOC392036 7 similar to zinc finger protein 43 (HTF6) DKFZp434L192 7p11.2 hypothetical protein DKFZp434L192 LOC392037 7 similar to hypothetical protein 9630041N07 LOC389495 7 LOC389495 LOC392916 7 similar to capicua homolog LOC392681 7 LOC392681
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 2142 - 225 - Ewing (2007)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineadrenal gland   highly
    Reproductivefemale systemuteruscervix highly
    Urinarykidney   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an N-terminal DXDX(T/V) motif that serves as an intermediate phosphoryl accepto
  • three motifs with P-type ATPases and haloacid dehalogenases
  • mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to murine Psph
    Homologene
    FAMILY
  • haloacid dehalogenase (HAD)-like hydrolase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • catalyzing the last step of serine biosynthesis
  • catalyzes magnesium-dependent hydrolysis of L-phosphoserine and is also involved in an exchange reaction between L-serine and L-phosphoserine
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    repressed by by l-serine and therefore the serine biosynthesis pathway is regulated by demand rather than supply which makes PSPH the rate-limiting enzyme in this pathway (Tabatabaie 2010)
    ASSOCIATED DISORDERS
    corresponding disease(s) PSPHD
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS