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FLASH GENE
Symbol PSPC1 contributors: mct/pgu - updated : 16-01-2019
HGNC name paraspeckle component 1
HGNC id 20320
Location 13q12.11      Physical location : 20.248.895 - 20.357.083
Synonym name paraspeckle protein 1
Synonym symbol(s) FLJ10955, PSP1, PSP1alpha, DKFZp566B1447
DNA
TYPE functioning gene
STRUCTURE 108.28 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 2077 58.7 523 - PMID: 16148043
also called alpha isoform
- - 1180 - 393 - PMID: 20573717
also called beta isoform
9 - 1815 - 417 - -
9 - 2526 - 523 - -
7 - 4509 - 393 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Lymphoid/Immunethymus    
Nervousbrain    
Reproductivemale systemtestis  highly Homo sapiens
Respiratorylung    
Urinarykidney    
cells
SystemCellPubmedSpeciesStageRna symbol
ReproductiveSertoli cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
Text in human embryonic stem cells (hESCs)
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two RNA recognition motifs (RRM, RBD or RNP)
  • PSP-1 RNA binding domain, required for its colocalization with NEAT1 RNA in paraspeckles, and NEAT1 RNA binds with paraspeckle proteins
  • a NOPS domain, characteristic of DBHS proteins, specifically binding to RRM2 of the partner DBHS protein
  • C-terminal coiled-coil motif essential for paraspeckle localization
  • mono polymer heteromer , dimer
    HOMOLOGY
    intraspecies homolog to NONO
    Homologene
    FAMILY
  • DBHS (Drosophila melanogaster behavior, human splicing) family
  • PSPC family
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    intracellular,nuclear envelope,matrix attachement regions
    text
  • localized in paraspeckels (a novel nuclear compartment)
  • predominately nuclear
  • basic FUNCTION
  • may be regulating multiple phases of important nuclear events during spermatogenesis
  • core paraspeckle protein
  • multifunctional nuclear proteins, implicated in subnuclear body formation, transcription initiation, coactivation and corepression, constitutive and alternative splicing, transcriptional termination, and DNA repair
  • with SFPQ and NONO, may cooperatively regulate androgen receptor-mediated gene transcription
  • critical to the control of gene expression through the nuclear retention of RNA containing double-stranded RNA regions that have been subject to adenosine-to-inosine editing
  • important role of NONO, PSPC1 within the circadian oscillator
  • overlapping or redundant roles of NONO, PSPC1, SFPQ as transcriptional cofactors at circadian clock-regulated genes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • PSPC1/NONO heterodimer has a right-handed antiparallel coiled-coil that positions two of four RNA recognition motif domains in an unprecedented arrangement
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction between LMX1B and PSPC1 in a larger protein complex also containing SFPQ
  • cell & other
  • nucleolus a transcription-dependent fashion
  • REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS