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FLASH GENE
Symbol PSPC1 contributors: mct/pgu - updated : 16-01-2019
HGNC name paraspeckle component 1
HGNC id 20320
Location 13q12.11      Physical location : 20.248.895 - 20.357.083
Synonym name paraspeckle protein 1
Synonym symbol(s) FLJ10955, PSP1, PSP1alpha, DKFZp566B1447
DNA
TYPE functioning gene
STRUCTURE 108.28 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC343717 13q12.11 similar to Zinc finger protein 85 (Zinc finger protein HPF4) (HTF1) LOC197049 13q12.11 hypothetical LOC197049 LOC341752 13q12.11 similar to fem-1 homolog a (C.elegans) LOC283523 13q12.11 similar to telomeric repeat binding factor 1 isoform 2; Telomeric repeat binding factor 1; telomeric repeat binding protein 1 LOC390372 13 similar to h2-calponin LOC390373 13 similar to SNAG1 LOC387899 13 hypothetical gene supported by NM_032250 LOC342827 13q12.11 similar to PHD finger protein 2 isoform b LOC387900 13 similar to FSHPRH1 protein LOC221136 13q12.11 similar to Mucin 5B precursor (Mucin 5 subtype B, tracheobronchial) (High molecular weight salivary mucin MG1) (Sublingual gland mucin) LOC390374 13 similar to hypothetical protein FLJ20297 TUBA2 13q11.2 tubulin, alpha 2 LOC390375 13 similar to paraspeckle protein 1 alpha isoform MRPL3P1 13q12.11 mitochondrial ribosomal protein L3 pseudogene 1 LOC221140 13q12.11 hypothetical LOC221140 LOC144848 13q12.11 similar to Vault poly(ADP-ribose) polymerase (VPARP) (193-kDa vault protein) (PARP-related/IalphaI-related H5/proline-rich) (PH5P) LOC390376 13 similar to Mitochondrial ornithine transporter 1 (Solute carrier family 25, member 15) TPIP 13q12.11 TPTE and PTEN homologous inositol lipid phosphatase HCP32 13q12.11 cytochrome c, somatic pseudogene ESRRAP 13q12.1 estrogen-related receptor alpha pseudogene LOC341757 13q12.11 similar to H63 breast cancer expressed gene isoform a; gene associated with HER-2/neu overexpression HSMPP8 13q12.11 M-phase phosphoprotein, mpp8 PSPC1 13q12-11 paraspeckle component 1 LOC390377 13 similar to Alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetylgalactosaminide alpha-2,6-sialyltransferase (NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc-alpha-2,6-sialyltransferase) (ST6GalNAc IV) (Sialyltransferase 7D) (Sialyltransfer ZNF237 13q11-q12 zinc finger protein 237 LOC387901 13 LOC387901 ZNF198 13q11-q12 zinc finger protein 198 LOC144845 13q12.11 hypothetical protein BC008631 GJA3 13q11 gap junction protein, alpha 3, 46kDa (connexin 46) LOC390378 13 similar to peptidylprolyl isomerase A GJB2 13q11-q12.1 gap junction protein, beta 2, 26kDa (connexin 26) GJB6 13q12.1 gap junction protein, beta 6 (connexin 30) CRYL1 13q11 crystallin, lambda 1 TG737 13q12.1 crystallin, lambda 1 IL17D 13q12.11 interleukin 17D LOC221143 13q12.11 hypothetical protein LOC221143 XPO4 13q11 exportin 4 LOC390379 13 similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP) LOC387902 13 similar to protein 40kD LATS2 13q11-q12 LATS, large tumor suppressor, homolog 2 (Drosophila) LOC338870 13q12.11 similar to ribosomal protein S12 LOC390380 13 similar to chromosome 9 open reading frame 12; 1,3,4,5,6-pentakisphosphate 2-kinase SAP18 13q12.11 sin3-associated polypeptide, 18kDa C13orf3 13q11 chromosome 13 open reading frame 3 MRP63 13p11.1-q11 mitochondrial ribosomal protein 63 LOC387903 13 LOC387903 ESTRRA 13q12.11 estrogen-related receptor alpha pseudogene
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 2077 58.7 523 - PMID: 16148043
also called alpha isoform
- - 1180 - 393 - PMID: 20573717
also called beta isoform
9 - 1815 - 417 - -
9 - 2526 - 523 - -
7 - 4509 - 393 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Lymphoid/Immunethymus    
Nervousbrain    
Reproductivemale systemtestis  highly Homo sapiens
Respiratorylung    
Urinarykidney    
cells
SystemCellPubmedSpeciesStageRna symbol
ReproductiveSertoli cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
Text in human embryonic stem cells (hESCs)
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two RNA recognition motifs (RRM, RBD or RNP)
  • PSP-1 RNA binding domain, required for its colocalization with NEAT1 RNA in paraspeckles, and NEAT1 RNA binds with paraspeckle proteins
  • a NOPS domain, characteristic of DBHS proteins, specifically binding to RRM2 of the partner DBHS protein
  • C-terminal coiled-coil motif essential for paraspeckle localization
  • mono polymer heteromer , dimer
    HOMOLOGY
    intraspecies homolog to NONO
    Homologene
    FAMILY
  • DBHS (Drosophila melanogaster behavior, human splicing) family
  • PSPC family
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    intracellular,nuclear envelope,matrix attachement regions
    text
  • localized in paraspeckels (a novel nuclear compartment)
  • predominately nuclear
  • basic FUNCTION
  • may be regulating multiple phases of important nuclear events during spermatogenesis
  • core paraspeckle protein
  • multifunctional nuclear proteins, implicated in subnuclear body formation, transcription initiation, coactivation and corepression, constitutive and alternative splicing, transcriptional termination, and DNA repair
  • with SFPQ and NONO, may cooperatively regulate androgen receptor-mediated gene transcription
  • critical to the control of gene expression through the nuclear retention of RNA containing double-stranded RNA regions that have been subject to adenosine-to-inosine editing
  • important role of NONO, PSPC1 within the circadian oscillator
  • overlapping or redundant roles of NONO, PSPC1, SFPQ as transcriptional cofactors at circadian clock-regulated genes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • PSPC1/NONO heterodimer has a right-handed antiparallel coiled-coil that positions two of four RNA recognition motif domains in an unprecedented arrangement
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction between LMX1B and PSPC1 in a larger protein complex also containing SFPQ
  • cell & other
  • nucleolus a transcription-dependent fashion
  • REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS