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FLASH GENE
Symbol PSMF1 contributors: mct - updated : 28-06-2014
HGNC name proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
HGNC id 9571
Location 20p13-p12.2      Physical location : 1.093.905 - 1.148.424
Synonym symbol(s) PI31
DNA
TYPE functioning gene
STRUCTURE 48.00 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
C20orf99 20p13-p12.2 chromosome 20 open reading frame 99 SOX12 20p13 SRY (sex determining region Y)-box 12 C20orf98 20p13 chromosome 20 open reading frame 98 C20orf97 20p12.2-p13 chromosome 20 open reading frame 97 C20orf18 20p13 chromosome 20 open reading frame 18 C20orf140 20p13 chromosome 20 open reading frame 140 CSNK2A1 20p13 casein kinase 2, alpha 1 polypeptide TCF15 20p13 transcription factor 15 (basic helix-loop-helix) C20orf139 20p13 chromosome 20 open reading frame 139 LOC391226 20 similar to dJ850E9.1 (novel C2H2 type zinc finger protein similar to Drosophila Scratch (Scrt), Slug and Xenopus Snail) C20orf54 20p13 chromosome 20 open reading frame 54 RPS10L 20p13 ribosomal protein S10-like C20orf55 20p13 chromosome 20 open reading frame 55 ANGPT4 20p13 angiopoietin 4 LOC343637 20p13 similar to dJ824F16.3 (novel protein similar to mouse thrombospondin type 1 domain protein R-spondin) PSMF1 20p13-p12.2 proteasome (prosome, macropain) inhibitor subunit 1 (PI31) ACTGP3 20p13 actin, gamma pseudogene 3 C20orf46 20p13 chromosome 20 open reading frame 46 SNPH 20p13 syntaphilin SDCBP2 20p13 syndecan binding protein (syntenin) 2 FLJ20802 20p13 hypothetical protein FLJ20802 FKBP1A 20p13 FK506 binding protein 1A, 12kDa NSFL1C 20p13 NSFL1 (p97) cofactor (p47) PTPNS1L3 20p12.2-13 protein tyrosine phosphatase, non-receptor type substrate 1-like 3 PTPNS1L2 20p13 protein tyrosine phosphatase, non-receptor type substrate 1-like 2 SIRPB1 20p13 signal-regulatory protein beta 1 SIRPB2 20p13 signal-regulatory protein beta 2 LOC391227 20 similar to Signal-regulatory protein beta-2 precursor (SIRP-beta-2) (SIRP-b2)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 3158 - 99 - Conticello
- - 3204 - 271 - Conticello
- - 3241 - 271 - Conticello
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveintestinesmall intestine   
Gustatory (taste)tongue    
Lymphoid/Immunethymus    
Reproductivefemale systemuteruscervix  
Skin/Tegumentskin    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • proline rich protein particulary within its C-terminal half where one fourth of amino-acids are proline
  • secondary structure
  • FBXO7 FP domain adopts an alpha/beta-fold similar to that of the PSMF1 FP domain
  • mono polymer monomer
    HOMOLOGY
    interspecies ortholog to chimpanzee LOC458030
    ortholog to murine Psmf1
    Homologene
    FAMILY proteasome inhibitor PI31 family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • control of proteasome function including that in ubiquitin-dependent pathway of protein degradation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • FP (FBXO7/PSMF1) domains found in the F-box protein FBXO7 and the proteasome inhibitor PSMF1 mediate the homodimerization and heterodimerization of FBXO7 and PSMF1
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • FBXO7 interacts with proteins that are not substrates of the ubiquitin proteasome system, such as CDK6 and PSMF1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS