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FLASH GENE
Symbol PSME2 contributors: mct - updated : 02-05-2017
HGNC name proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
HGNC id 9569
Location 14q11.2      Physical location : 24.612.574 - 24.615.855
Synonym name
  • MCP activator, 31kDa subunit
  • activator of multicatalytic protease subunit 2
  • 11S regulator complex subunit beta
  • Synonym symbol(s) PA28B, PA28beta, REG-beta
    DNA
    TYPE functioning gene
    STRUCTURE 3.00 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    regionally located tightly linked to PSME1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 829 27 239 - -
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Psme2b
    homolog to murine Psme2
    homolog to rattus Psme2
    intraspecies homolog to Ki antigen
    Homologene
    FAMILY
  • PSM,proteasome
  • PA28 family
  • CATEGORY chaperone/stress , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • proteasome activator
  • implicated in immunoproteasome assembly and required for efficient antigen processing
  • the PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasmoe
  • CELLULAR PROCESS protein, degradation
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimer of PSME1 and PSME2 forming a hexadimeric ring
  • ATP-dependent association of PA28 and porteasome
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PSME1
  • NAA10 suppresses 28S proteasome activity through interaction with PSME2
  • cell & other
    REGULATION
    Other stimulated by interferon gamma
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    Pa28 knockout mice