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FLASH GENE
Symbol PSME1 contributors: mct/npt - updated : 10-07-2008
HGNC name proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
HGNC id 9568
Location 14q11.2      Physical location : 24.605.377 - 24.608.175
Synonym name
  • MCP activator,29kDa subunit
  • proteasome activator 28 subunit alpha
  • 11S regulator complex subunit alpha
  • interferon gamma up-regulated I-5111 protein
  • Synonym symbol(s) PA28A, PA28alpha, IFI5111, MGC8628, REGalpha
    DNA
    TYPE functioning gene
    STRUCTURE 2.00 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - D14S64 - PSME1 ,PSME2 - D14S275 - qter
    Authors McCusker (97)
    Physical map
    DHRS4 14q11.2-14q21.3 dehydrogenase/reductase (SDR family) member 4 DHRS4L2 14 dehydrogenase/reductase (SDR family) member 4 like 2 LOC387975 14 similar to peroxisomal short-chain alcohol dehydrogenase; NADP-dependent retinol dehydrogenase; NADPH-dependent retinol dehydrogenase/reductase LOC90668 14q11.2 hypothetical protein BC008134 CPNE6 14q11.2 copine VI (neuronal) NRL 14q11.1-q11.2 neural retina leucine zipper PCK2 14q11.2-q12 phosphoenolpyruvate carboxykinase 2 (mitochondrial) WDR23 14q11.2 WD repeat domain 23 LOC161247 14q11.2 similar to 1110028A07Rik protein PSME1 14q11.2 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) C14orf122 14q11.2 chromosome 14 open reading frame 122 PSME2 14q11.2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) RNF31 14q11.2 ring finger protein 31 ISGF3G 14q11.2 interferon-stimulated transcription factor 3, gamma 48kDa REC8L1 14q11.2-q12 REC8-like 1 (yeast) IPO4 14q11.2 importin 4 TM9SF1 14q11.2 transmembrane 9 superfamily member 1 C14orf20 14q11.2 chromosome 14 open reading frame 20 C14orf123 14q11.2 chromosome 14 open reading frame 123 MGC5987 14q11.2 hypothetical protein MGC5987 NEDD8 14q11.2 neural precursor cell expressed, developmentally down-regulated 8 GMPR2 14q11.2 guanosine monophosphate reductase 2 TINF2 14q11.2 TERF1 (TRF1)-interacting nuclear factor 2
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 1012 28 249 - Zhang (2007)
    - - 1187 - 250 - Zhang (2007)
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepharynx   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • the KEKE motif promoting binding of protein with this structural feature
  • mono polymer homomer , heteromer , dimer , heptamer
    HOMOLOGY
    interspecies homolog to murine Psme1
    homolog to rattus Psme1
    intraspecies homolog to Ki antigen
    Homologene
    FAMILY
  • PSM, proteasome
  • PA28 family
  • CATEGORY chaperone/stress , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION
  • implicated in immunoproteasome assembly and required for efficient antigen processing
  • plays an important role in the generation of MHC ligands by proteasomes
  • the PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome
  • involved in the presentation of endogenous antigens by MHC class I molecules
  • its function is particularly relevant for the generation of normally poorly excised peptide products
  • CELLULAR PROCESS protein, degradation
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
  • component 260 S proteasome hexameric activator
  • heterodimer of PSME1 and PSME2 forming a hexadimeric ring
  • able to form homoheptamers
  • ATP dependent association of PA28 and proteasome
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PSME1
  • PSME2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    Pa28 knockout mice