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FLASH GENE
Symbol PSMD9 contributors: - updated : 02-06-2007
HGNC name proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
HGNC id 9567
Location 12q24.31-q24.32      Physical location : 122.326.645 - 122.355.770
Synonym name
  • 26S proteasome regulatory subunit p27
  • homolog of rat Bridge 1
  • Synonym symbol(s) NAS2, MGC8644, p27
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem
    STRUCTURE 29.00 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned   linked   status confirmed
    RNA
    TRANSCRIPTS type messenger
    text with two alternatively spliced isoforms
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - - 24.8 223 - Watanabe
    - - - - 228 209 - Watanabe
    - - - - 223 - Watanabe
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
     stomach   highly
    Nervousnervecranial nerve  highly
    Skin/Tegumentskin   highly
    Urinarykidney    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    a PDZ (DHR) domain
    HOMOLOGY
    interspecies homolog to yeast S.cerevisiae NAS2 gene
    Homologene
    FAMILY PSM, proteasome family, proteasome subunit p27 family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • 19/22S regulator of proteasome, non ATPase subunit p27
  • acting as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component 26 S (prosome-macropain) of multicatalytic proteinase complex of proteasome
  • subunit of the modulator trimer complex that stimulates the association of the PA700 regulator with the catalytic 20S proteasome to form the ATP-dependent active 26S proteasome
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS