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FLASH GENE

Symbol

PSMD6

contributors: - updated : 06-05-2005

HGNC name	proteasome (prosome, macropain) 26S subunit, non-ATPase, 6
HGNC id	9564

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	3p14.1      Physical location : 63.996.230 - 64.009.120
Synonym name	proteasome regulatory particle subunit p44S10
Synonym symbol(s)	S10, p44S10, KIAA0107, SGA-113M, PFAAP4

DNA

TYPE	functioning gene
STRUCTURE	12.00 kb     8 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type	ubiquitous

constitutive of

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive stomach       highly Lymphoid/Immune thymus       highly Reproductive female system breast mammary gland   highly   female system ovary     moderately   female system uterus     moderately   male system prostate     moderately Respiratory respiratory tract larynx     predominantly Skin/Tegument skin       highly Visual eye       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a PCI domain

mono polymer

complex

HOMOLOGY

Homologene

FAMILY

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm

basic FUNCTION

acting as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins

CELLULAR PROCESS

protein, ubiquitin dependent proteolysis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	PA700 complex
	proteasome

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   amplification --over   during progression of cutaneous malignant melanoma

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS