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FLASH GENE
Symbol PSMD3 contributors: mct - updated : 19-05-2012
HGNC name proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
HGNC id 9560
Location 17q21.1      Physical location : 38.137.059 - 38.154.212
Synonym name
  • 26S proteasome regulatory subunit S3
  • proteasome subunit p58
  • Synonym symbol(s) S3, P58, RPN3
    DNA
    TYPE functioning gene
    STRUCTURE 17.15 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 2174 60.8 534 - 2010 20172861
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a PCI domain
  • HOMOLOGY
    interspecies homolog to yeast S.cerevisiae Sun2p
    Homologene
    FAMILY
  • proteasome subunit S3 family
  • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • acting as a regulatory subunit of the 26 S proteasome involved in the ATP-dependent degradation of ubiquitinated proteins
  • significant contribution of PSMD3-CSF3 and PLCB4 loci to the regulation of neutrophil count
  • CELLULAR PROCESS protein, degradation
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • one of the non-ATPase subunits of the 19S regulator lid
  • non-ATPase subunit 3 of the 26S proteasome (prosome macropain)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS