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FLASH GENE

Symbol

PSMD2

contributors: mct - updated : 12-01-2017

HGNC name	proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
HGNC id	9559

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	3q27.1      Physical location : 184.017.021 - 184.026.840
Synonym name	identical to tumor-necrosis-factor-receptor associated protein 2/55.11 type protein 55.11
	tumor necrosis factor type 1 receptor-associated protein 2
	proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
	protein 55.11
Synonym symbol(s)	HRD2P, TRAP2, P97, RPN1, S2,

DNA

TYPE	functioning gene
STRUCTURE	9.97 kb     21 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

tentative : very preliminary evidence

Map	cen - D13S459 - ACTN2 - RYR2 - D13S2785 - PM - D13S304 - pter
Authors	Gene Map (99)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_002808 21 - 3076 NP_002799 - 908 - 1996 8774743 NM_001278708 19 - 2655 NP_001265637 - 778 - 1996 8774743 NM_001278709 19 - 2644 NP_001265638 - 744 - 1996 8774743

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

seven PC repeats

HOMOLOGY

Homologene

FAMILY

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus,nucleoplasm

basic FUNCTION

acting as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins

CELLULAR PROCESS

protein

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

important fonctional component of the proteosome and in the degradation

INTERACTION

DNA

RNA

small molecule

protein

RPGRIP1L controls likely ciliary signaling by regulating the activity of the ciliary proteasome via PSMD2

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	novel prognostic markers in acute myeloid leukemia with favorable outcome are PSMD2, PPARD
Therapy target
	System Type Disorder Pubmed cancer lung   potential therapeutic target in association with various clinicopathologic features in lung adenocarcinomas

ANIMAL & CELL MODELS