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FLASH GENE
Symbol PSMD11 contributors: mct - updated : 03-09-2013
HGNC name proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
HGNC id 9556
Location 17q11.2      Physical location : 30.771.501 - 30.808.041
Synonym name
  • 26S proteasome regulatory subunit 9
  • 26S proteasome regulatory subunit S9
  • 26S proteasome regulatory subunit p44.5
  • Synonym symbol(s) PSDB, S9, Rpn6, p44.5, MGC3844
    DNA
    TYPE functioning gene
    STRUCTURE 38.86 kb     14 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    BLMH 17q11.2 bleomycin hydrolase LOC388364 17 similar to AWKS9372 CPD 17q11.2 carboxypeptidase D GOSR1 17q11.2 golgi SNAP receptor complex member 1 LOC390784 17 similar to Arachidonate 12-lipoxygenase, 12S-type (12-LOX) (Platelet-type lipoxygenase 12) LOC388365 17 LOC388365 DKFZP434O047 17q11.2 DKFZP434O047 protein LOC284089 17q11.2 similar to keratin 17 LOC388366 17 LOC388366 DKFZp667M2411 17q11.2 hypothetical protein DKFZp667M2411 LOC388367 17 similar to Joined to JAZF1 CRLF3 17q11.2 cytokine receptor-like factor 3 FLJ12735 17q11.2 cytokine receptor-like factor 3 FLJ22729  hypothetical protein FLJ22729 CENTA2 17q11.2 centaurin, alpha 2 RNF135 17q11.2 ring finger protein 135 NF1 17q11.2 neurofibromin 1 (neurofibromatosis, von Recklinghausen disease, Watson disease) OMG 17q11.2 oligodendrocyte myelin glycoprotein EVI2B 17q11.2 ecotropic viral integration site 2B EVI2A 17q11.2 ecotropic viral integration site 2A AK3P1 17q11.2 adenylate kinase 3 pseudogene 1 RAB11-FIP4  rab11-family interacting protein 4 LOC339281 17q11.2 hypothetical LOC339281 HSA272196 17q11.2 hypothetical protein, clone 2746033 HCA66 17q11.2 hepatocellular carcinoma-associated antigen 66 JJAZ1 17q11.2 hepatocellular carcinoma-associated antigen 66 LOC114659  KIAA0563-related gene LOC390785 17 hypothetical gene supported by NM_019613 ARHT1 17q11.2-q12 ras homolog gene family, member T1 RHBDL4 17q11.2 rhomboid, veinlet-like 4 (Drosophila) NJMU-R1 17q12 protein kinase Njmu-R1 ZNF207 17q11.2 zinc finger protein 207 PSMD11 17q12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 CDK5R1 17p11.2-q11 cyclin-dependent kinase 5, regulatory subunit 1 (p35) MYO1D 19p13.3-p13.2 myosin ID DKFZP564K1964 17q12 DKFZP564K1964 protein SPACA3 17q12 sperm acrosome associated 3 ACCN1 17q11.2-q12 amiloride-sensitive cation channel 1, neuronal (degenerin) LOC339212 17q12 similar to tousled-like kinase 2; serine/threonine kinase; tousled-like kinase CCL2 17q11.2-q21.1 chemokine (C-C motif) ligand 2 CCL7 17q11.2-q12 chemokine (C-C motif) ligand 7 CCL11 17q21.1-q21.2 chemokine (C-C motif) ligand 11 CCL8 17q11.2 chemokine (C-C motif) ligand 8 CCL13 17q11.2 chemokine (C-C motif) ligand 13 CCL1 17q11.2 chemokine (C-C motif) ligand 1 LOC124842 17q12 hypothetical protein LOC124842
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 3914 - 422 - 2009 19616115
    13 - 4035 - 422 - 2009 19616115
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one PCI domain
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Psmd11 (99.8pc)
    homolog to C-Elegans Rpn-6
    homolog to rattus Psmd11 (100.00pc)
    Homologene
    FAMILY
  • proteasome subunit S9 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • acting as a regulatory subunit of the 26s proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins
  • has a pivotal role in stabilizing the otherwise weak interaction between the CP (core particle) and the RP (regulatory particle)
  • critical role for the integrity of the 26S proteasomes complex
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • PA700 complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction of AMPK with one of these novel interacting proteins, the non-ATPase subunit of the proteasome PSMD11
  • USP4, a deubiquitylating enzyme with specificity for both Lys48 and Lys63 ubiquitin chains, interacts with the PSMD11 subunit of the proteasome via an internal ubiquitin-like (UBL) domain
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS